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Table 3 Clinical examination in step 3, according to the diagnosis means

From: Assessment of work-related asthma prevalence, control and severity: protocol of a field study

  in all centers where possible
STAGE 1 • detailed medical interview (occupational exposures, medical history and symptoms)
• extended OASYS protocol (4–6 weeks)
• skin-prick-tests to common airborne allergens and to potentially allergenic occupational agents
• flow-volume curves with beta2 agonist reversibility test
• methacholine challenge test
• total serum IgE measurements and,
• if possible, allergen specific IgE
• exhaled Nitric Oxyde measurements
• induced sputum to make a cytological analysis (polynuclear cells, neutrophils and eosinophils)
(if suspected WRA)
• one or several specific inhalation challenge (SIC) with the potential occupational allergen
• one bronchial exposure test at the work station
• comparative methacholine challenge tests, in working period and resting period.
• comparative exhaled Nitric Oxyde measurements before and after exposure
• induced sputum cytologic analysis before and after exposure