Measure | Parameter | k | Estimate | P value estimate | P value of Q | I2 | R2 | p covariates |
---|---|---|---|---|---|---|---|---|
Meta-regression analysis of SMR studies | ||||||||
 SMR | No covariate | 63 | 1.55 (1.38–1.75) | <0.0001 | <0.0001 | 96.18 |  |  |
 Univariate model | Year of publication | 63 | 2.30E + 18 (2.41E + 08–2.19E + 28) | 0.003 | <0.0001 | 95.44 | 15.12 | 0.000 |
Industry | 63 | 1.15 (0.86–1.53) | 0.353 | <0.0001 | 95.71 | 8.15 | 0.027 | |
Person-years of follow-up | 22 | 1.53 (1.25–1.87) | <0.0001 | <0.0001 | 94.73 | 13.4 | 0.050 | |
NOS score | 63 | 3.53 (2.27–5.49) | <0.0001 | <0.0001 | 95.11 | 19.18 | 0.000 | |
Number of subjects | 63 | 1.69 (1.48–1.92) | <0.0001 | <0.0001 | 95.43 | 10.89 | 0.008 | |
Total number of deaths | 54 | 1.69 (1.48–1.94) | <0.0001 | <0.0001 | 95.31 | 13.94 | 0.006 | |
 Multivariate model | Industry, year of publication | 63 | 1.07E + 19 (3.85E + 09-2.97E + 28) | <0.0001 | <0.0001 | 94.65 | 25.51 | <0.0001 |
Industry, year of publication, geographical location | 63 | 1.04E + 20 (4.90E + 10-2.21E + 29) | <0.0001 | <0.0001 | 94.3 | 28.85 | <0.0001 | |
Industry, year of publication, geographical location, number of subjects | 63 | 1.80E + 17 (1.67E + 08-1.94E + 26) | <0.0001 | <0.0001 | 93.18 | 37.41 | <0.0001 | |
Industry, year of publication, geographical location, number of subjects, NOS score | 63 | 1.06E + 16 (5.27E + 06-2.12E + 25) | 0.001 | <0.0001 | 93.05 | 37.04 | <0.0001 | |
Industry, year of publication, geographical location, number of subjects, total deaths | 54 | 5.32E + 18 (1.07E + 08-2.65E + 29) | 0.001 | <0.0001 | 92.72 | 34.76 | <0.0001 | |
Industry, year of publication, geographical location, NOS score | 63 | 1.29E + 17 (3.61E + 07-4.61E + 26) | <0.0001 | <0.0001 | 93.77 | 32.23 | <0.0001 | |
Person-years of follow-up, industry | 22 | 1.22 (0.76–1.96) | 0.408 | <0.0001 | 94.12 | 13.87 | 0.086 | |
Person-years of follow-up, industry, year of publication | 22 | 2.80E + 14 (2.88E-08-2.73E + 36) | 0.198 | <0.0001 | 92.81 | 17.99 | 0.079 | |
Person-years of follow-up, industry, year of publication, geographical location | 22 | 1.55E + 23 (4.66E-02-5.12E + 47) | 0.064 | <0.0001 | 92.31 | 23.08 | 0.056 | |
Person-years of follow-up, number of subjects | 22 | 1.62 (1.31–2.00) | <0.0001 | <0.0001 | 92.9 | 17.36 | 0.055 | |
Meta-regression analysis of SIR studies | ||||||||
 SIR | No covariate | 19 | 1.68 (1.45–1.96) | <0.0001 | <0.0001 | 74.51 |  |  |
 Univariate model | Year of publication | 19 | 7.92E + 11 (3.71E-02-1.69E + 25) | 0.080 | <0.0001 | 72.31 | 4.27 | 0.086 |
Industry | 19 | 1.37 (0.97–1.95) | 0.077 | <0.0001 | 70.88 | 11.68 | 0.214 | |
Number of subjects | 19 | 1.88 (1.55–2.28) | <0.0001 | <0.0001 | 69.94 | 18.16 | 0.086 | |
Total number of deaths | 5 | 1.29 (1.05–1.59) | 0.017 | 0.687 | 0 | 100 | 0.017 | |
 Multivariate model | Number of subjects, exposure level | 19 | 2.09 (1.47–2.96) | <0.0001 | <0.0001 | 72.12 | 9.02 | 0.197 |
 | Number of subjects, NOS score | 19 | 3.01 (1.52–5.95) | 0.002 | <0.0001 | 69.36 | 15.16 | 0.087 |
 | Number of subjects, industry | 19 | 1.71 (1.03–2.85) | 0.037 | <0.0001 | 70.28 | 10.84 | 0.229 |
Meta- regression of silicotic studies | ||||||||
 SMR | Year of publication | 24 | 7.03E + 21 (5.05E + 04-9.79E + 38) | 0.013 | <0.0001 | 92.23 | 20.55 | 0.014 |
Year of publication, total number of deaths | 20 | 1.59E + 23 (1.60E + 05-1.57E + 41) | 0.012 | <0.0001 | 86.98 | 42.87 | 0.002 | |
Year of publication, total number of deaths, geographical location, industry | 20 | 4.61E + 22 (2.40E + 03-8.85E + 41) | 0.021 | <0.0001 | 86.9 | 33.84 | 0.022 | |
Year of publication, total number of deaths, industry | 20 | 6.07E + 22 (1.43E + 04-2.58E + 41) | 0.017 | <0.0001 | 87.46 | 38.8 | 0.002 | |
Year of publication, total number of deaths, geographical location | 20 | 9.89E + 22 (2.24E + 04-4.37E + 41) | 0.016 | <0.0001 | 86.65 | 38.3 | 0.007 | |
Year of publication, geographical location | 24 | 1.26E + 22 (3.90E + 04-4.08E + 39) | 0.013 | <0.0001 | 92.05 | 16.98 | 0.050 |