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Table 1 Characteristics of silicotic and non-silicotic studies

From: Occupational exposure to silica dust and risk of lung cancer: an updated meta-analysis of epidemiological studies

  Author, Year Country Industry Covariates adjusted for Number of subjects Outcome examined Measure, silicotic status Effect Estimate (95 % CI) Observed lung cancer deaths or cases
  Cohort studies
1 Amandus, 1995 [25] USA Mixed Age, sex, race, talc, asbestos 760 Mortality SMR, silicotic 2.30 (1.50–3.40)  
2 Berry, 2003 [28] Australia Mixed Age, sex, calendar period, smoking 1467 Mortality SMR, silicotic 1.90 (1.50–2.30) 94
3 Carta, 2001 [31] Sardinia Mine & quarries Age, sex, calendar period 724 Mortality SMR, silicotic 1.37 (0.98–1.91) 34
4 Chan, 2000 [33] Hong Kong Mixed Age, sex, calendar period 1502 Mortality SMR, silicotic 1.94 (1.35–2.70) 33
5 Chen, 1992 [34] China Mixed Age, sex 70179 Mortality SMR, silicotic 1.22 (0.90–1.60)  
6 Chen, 1990 [35] China Iron mine Age, sex 1226 Mortality SMR, silicotic 5.30 (2.90–8.80) 14
       Mortality SMR, non-silicotic 2.90 (1.60–4.70) 15
7 Chen, 2006 [37] China Mine Age, sex 932 Mortality SMR, silicotic 4.13 (3.15–5.29)  
       Mortality SMR, non-silicotic 1.96 (1.50–2.73)  
8 Chia, 1991 [39] China granite Age, sex, calendar period 159 Incidence SIR, silicotic 2.01 (0.92–3.81) 9
9 Chiyotani, 1990 [40] Japan Mixed Age, sex 1941 Mortality SMR, silicotic 6.03 (5.29–6.77) 44
10 Finkelstein, 1982 [10] Canada mine Age, sex, calendar period 1190 Mortality SMR, silicotic 2.30 (1.80–3.00) 62
11 Finkelstein, 1995 [43] Canada Mixed Age, sex 328 Incidence SIR, silicotic 2.55 (1.43–8.28) 15
       Incidence SIR, non-silicotic 0.90 (0.51–1.47) 16
12 Goldsmith, 1995 [49] USA Mixed Age, sex, calendar period 590 Mortality SMR, silicotic 1.90 (1.35–2.60) 39
13 Infante- Rivard, 1989 [54] Canada Mixed Age, sex, calendar period 1072 Mortality SMR, silicotic 3.47 (3.11–3.90) 83
14 Marinaccio, 2006 [63] Italy Mixed Age, sex, calendar period 14929 Mortality SMR, silicotic 1.10 (1.03–1.18) 798
15 Mehnert, 1990 [64] Germany quarry age, sex 2475 Mortality SMR, silicotic 1.83 (0.84–3.48) 9
       Mortality SMR, non-silicotic 0.91 (0.54–1.44) 18
16 Merlo, 1995 [67] Italy Mixed Age, sex, calendar period 450 Mortality SMR, silicotic 3.50 (2.44–4.87) 35
17 Ng, 1990 [71] Hong Kong Mixed Age, sex, PAH, asbestos 1419 Mortality SMR, silicotic 2.03 (1.35–2.93) 28
18 Partanen, 1994 [73] Finland Mixed Age, sex, calendar period 811 Incidence SIR, silicotic 2.89 (2.35–3.48) 190
19 Puntoni, 1988 [105] Italy Refractory brick Age, sex 231 Mortality SMR, silicotic 1.67 (0.61–3.64) 6
       Mortality SMR, non-silicotic 2.08 (0.67–4.84) 5
20 Scarselli, 2011 [81] Italy Mixed Age, sex, calendar period 2034 Mortality SMR, silicotic 1.39 (1.17–1.64) 139
21 Sherson, 1991 [83] Denmark Foundry Age, sex, calendar period 6144 Incidence SIR, silicotic 1.71 (0.85–3.06) 11
       Incidence SIR, non-silicotic 1.30 (1.07–1.47) 150
22 Tornling, 1991 [88] Sweden Ceramic Age, sex 280 Mortality SMR, silicotic 2.36 (1.07–4.48) 9
23 Tse, 2014 [90] Hong Kong Mixed Age, sex, calendar period 3202 Mortality SMR, silicotic 1.86 (1.59–2.17) 157
24 Wang, 1996 [96] China Metallurgy Age, sex, calendar period 4372 Mortality SMR, silicotic 2.37 (1.96–2.86) 104
25 Westerholm, 1980 [9] Sweden Mixed Age, sex, calendar period 3610 Mortality SMR, silicotic 3.80 (2.30–5.80)  
26 Westerholm, 1986 [99] Sweden Mixed Age, sex, calendar period 712 Mortality SMR, silicotic 5.38 (2.20–11.10) 7
27 Yu, 2008 [102] Hong Kong mixed Age, calendar period, smoking 2798 Mortality SMR, silicotic 1.56 (0.98–2.63) 86
28 Zambon, 1987 [103] Italy Mixed Age, sex, calendar period 1313 Mortality SMR, silicotic 2.39 (1.86–3.02) 70
  Case-control studies
 1 Forastiere, 1989 [45] Italy Mixed Age, sex, calendar period 595 Mortality MOR, silicotic 2.50 (1.20–4.60) 10
 2 Fu, 1994 [46] China Tin mine Age, sex, smoking 267 Incidence OR, silicotic 2.03 (1.25–3.29)  
 3 Lagorio, 1990 [61] Italy Pottery Age, calendar period, smoking 391 Mortality OR, silicotic 3.90 (1.80–8.30)  
       Mortality OR, non-silicotic 1.40 (0.70–2.80)  
 4 Neuberger, 1988 [70] Austria Mixed Age, sex, calendar period, area, smoking 2212 Mortality MOR, silicotic 1.41 (1.21–1.64) 182
 5 Schuller, 1986 [82] Switzerland Mixed Calendar period 2399 Mortality MOR, silicotic 2.23 (1.90–2.60) 180
 6 Tsuda, 2002 [91] Japan Mixed Age, sex, smoking 501 Mortality OR, silicotic 2.77 (1.60–4.77) 184
  1. CI confidence interval, USA United States of America, PAH polycyclic aromatic hydrocarbons, SMR standardized mortality ratio, SIR standardized incidence ratio OR odds ratio, MOR mortality odds ratio