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Table 4 Results of Cox regression analysis for hospitalization in patients diagnosed with influenza in the 2013/2014 season

From: Factors associated with hospitalization for seasonal influenza in a Japanese nonelderly cohort

 

Univariate Analysis

Multivariable analysis

HR

95.0 % CI

P

HR

95.0 % CI

P

Female

1.31

1.01 to 1.68

0.039

1.26

0.98 to 1.63

0.075

Age, (years)

 18–64

Ref.

 

<0.001

Ref.

 

<0.001

 <2

10.46

7.38 to 14.81

<0.001

12.02

8.07 to 17.91

<0.001

 2–4

3.32

2.31 to 4.79

<0.001

3.82

2.52 to 5.82

<0.001

 5–17

1.02

0.72 to 1.43

0.924

1.31

0.90 to 1.91

0.155

Comorbidity

 Asthma

2.27

1.76 to 2.94

<0.001

1.24

0.93 to 1.66

0.139

 COPD

5.72

2.70 to 12.14

<0.001

4.09

1.84 to 9.09

0.001

 Cerebrovascular disease

3.08

0.99 to 9.62

0.053

2.28

0.70 to 7.47

0.173

 Diabetes mellitus

1.74

0.65 to 4.69

0.270

1.77

0.63 to 4.99

0.282

 Mental disorder

1.97

1.27 to 3.06

0.002

1.58

0.96 to 2.59

0.074

 Neurologic disease

2.32

1.54 to 3.48

<0.001

2.39

1.45 to 3.94

0.001

 Anemia

2.62

1.47 to 4.68

0.001

1.77

0.95 to 3.29

0.072

 Liver disease

1.25

0.56 to 2.82

0.586

0.90

0.38 to 2.15

0.816

 Dialysis

20.76

2.91 to 147.95

0.002

9.34

1.18 to 74.03

0.034

 Malignancy

2.70

1.00 to 7.24

0.049

2.00

0.71 to 5.65

0.192

 Regular steroid use

3.29

1.55 to 6.98

0.002

2.58

1.18 to 5.64

0.018

Respiratory co-infection

1.32

0.99 to 1.77

0.057

1.10

0.82 to 1.48

0.509

Virus type

 A

Ref.

 

<0.001

Ref.

 

0.002

 B

0.65

0.49 to 0.86

0.002

0.73

0.55 to 0.97

0.028

 Both A and B

2.62

1.38 to 4.97

0.003

2.23

1.17 to 4.26

0.015

  1. COPD chronic obstructive pulmonary disease
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