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Table 3 Results of Cox regression analysis for hospitalization in patients diagnosed with influenza

From: Factors associated with hospitalization for seasonal influenza in a Japanese nonelderly cohort

  Univariate Analysis Multivariable analysis
HR 95.0 % CI P HR 95.0 % CI P
Female 1.30 1.03 to 1.65 0.029 1.26 0.99 to 1.59 0.059
Age, (years)
 18–64 Ref.   <0.001 Ref.   <0.001
 <2 9.69 6.94 to 13.53 <0.001 12.25 8.37 to 17.93 <0.001
 2–4 3.58 2.56 to 5.00 <0.001 4.56 3.10 to 6.72 <0.001
 5–17 1.05 0.77 to 1.43 0.757 1.45 1.03 to 2.05 0.033
Comorbidity
 Asthma 2.12 1.66 to 2.70 <0.001 1.15 0.88 to 1.51 0.309
 COPD 5.79 2.87 to 11.70 <0.001 3.71 1.75 to 7.88 0.001
 Cerebrovascular disease 3.59 1.34 to 9.64 0.011 2.48 0.88 to 6.97 0.084
 Diabetes mellitus 2.37 1.05 to 5.32 0.037 2.18 0.92 to 5.19 0.076
 Mental disorder 1.93 1.28 to 2.92 0.002 1.41 0.89 to 2.25 0.144
 Neurologic disease 2.56 1.78 to 3.68 <0.001 2.62 1.68 to 4.11 <0.001
 Anemia 2.82 1.67 to 4.74 <0.001 1.90 1.09 to 3.31 0.024
 Liver disease 2.02 1.10 to 3.69 0.023 1.47 0.76 to 2.83 0.255
 Dialysis 16.09 2.26 to 114.66 0.006 5.87 0.77 to 44.89 0.088
 Malignancy 3.53 1.57 to 7.93 0.002 2.29 0.96 to 5.43 0.061
 Regular steroid use 3.22 1.60 to 6.51 0.001 2.35 1.12 to 4.91 0.024
Respiratory co-infection 1.26 0.97 to 1.65 0.082 1.06 0.81 to 1.38 0.689
Virus type
 A Ref.   <0.001 Ref.   0.002
 B 0.71 0.54 to 0.92 0.009 0.73 0.55 to 0.96 0.025
 Both A and B 2.80 1.48 to 5.28 0.002 2.21 1.16 to 4.22 0.016
Season
 2013/2014 Ref.    Ref.   
 2014/2015 0.83 0.59 to 1.17 0.283 0.82 0.57 to 1.17 0.267
  1. COPD chronic obstructive pulmonary disease