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Table 2 Multivariable logistic regression model: association of demographical and clinical features with late presentation according to observation period

From: The risk of late or advanced presentation of HIV infected patients is still high, associated factors evolve but impact on overall mortality is vanishing over calendar years: results from the Italian MASTER Cohort

  

Total period (n = 17333)

1985–1991 (n = 4254)

1992–1997 (n = 4614)

1998–2003 (n = 3892)

2004–2009 (n = 3142)

2010–2013 (n = 1431)

Variable

Category

ORs (95 % CI)

P value

ORs (95 % CI)

P value

ORs (95 % CI)

P value

ORs (95 % CI)

P value

ORs (95 % CI)

P value

ORs (95 % CI)

P value

Gender

Male vs Female

1.29 (1.19–1.40)

<0.001

1.18 (1.00–1.40)

0.054

1.45 (1.25–1.69)

<0.001

1.31 (1.12–1.54)

0.001

1.17 (0.97–1.42)

0.099

1.10 (0.82–1.46)

0.525

Age at enrollment

<25

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

25–34

2.44 (2.21–2.70)

<0.001

2.55 (2.20–2.97)

<0.001

2.99 (2.42–3.69)

<0.001

2.52 (1.88–3.39)

<0.001

1.48 (1.10–2.00)

0.009

1.58 (1.04–2.40)

0.032

35–44

4.11 (3.65–4.61)

<0.001

5.33 (4.04–7.02)

<0.001

4.84 (3.82–6.14)

<0.001

4.44 (3.29–6.01)

<0.001

2.49 (1.84–3.35)

<0.001

2.65 (1.74–4.03)

<0.001

45–54

5.79 (4.98–6.74)

<0.001

5.04 (2.90–8.73)

<0.001

5.20 (3.68–7.35)

<0.001

7.70 (5.35–11.08)

<0.001

3.57 (2.56–4.99)

<0.001

3.75 (2.39–5.90)

<0.001

≥55

7.45 (6.06–9.16)

<0.001

21.65 (6.07–77.22)

<0.001

8.06 (5.19–12.53)

<0.001

10.08 (6.27–16.19)

<0.001

4.19 (2.76–6.36)

<0.001

3.98 (2.29–6.94)

<0.001

Country of Origin

Others vs Italy

1.54 (1.38–1.73)

<0.001

1.91 (1.04–3.49)

0.036

0.94 (0.67–1.33)

0.742

1.53 (1.25–1.88)

<0.001

1.48 (1.21–1.81)

<0.001

1.52 (1.15–2.03)

0.004

HIV exposure category

MSM

Ref.

 

Ref.

 

Ref.

 

Ref

 

Ref.

 

Ref.

 

IDUs

1.27 (1.15–1.40)

<0.001

0.59 (0.43–0.80)

0.001

1.44 (1.18–1.76)

<0.001

1.27 (1.04–1.56)

0.017

1.18 (0.93–1.50)

0.172

2.12 (1.30–3.47)

0.003

Heterosexuals

1.52 (1.37–1.69)

<0.001

0.54 (0.37–0.77)

0.001

1.44 (1.15–1.81)

0.002

1.69 (1.39–2.06)

<0.001

1.73 (1.43–2.10)

<0.001

1.89 (1.42–2.50)

<0.001

MSM-IDUs

0.89 (0.59–1.34)

0.584

0.44 (0.21–0.93)

0.032

0.69 (0.34–1.38)

0.294

0.86 (0.32–2.30)

0.77

2.47 (0.61–9.97)

0.204

2.89 (0.25–32.84)

0.393

Heterosexuals-IDUs

1.88 (1.56–2.26)

<0.001

1.47 (0.95–2.27)

0.085

2.39 (1.73–3.29)

<0.001

1.42 (0.93–2.17)

0.106

0.67 (0.40–1.11)

0.121

1.07 (0.4–2.88)

0.896

Haemophilia /Perinatal transmission

0.84 (0.36–1.09)

0.574

0.26 (0.09–0.76)

0.014

0.55 (0.17–1.72)

0.302

1.73 (0.32–9.40)

0.528

1.43 (0.08–24.65)

0.808

2.01 (0.43–9.38)

0.373

Unknown

1.05 (0.42–1.10)

0.856

0.95 (0.14–6.53)

0.958

1.21 (0.43–3.36)

0.718

1.89 (0.16–22.73)

0.617

1.50 (0.52–4.36)

0.456

0.79 (0.35–1.81)

0.582

Others

1.43 (0.83–1.20)

0.001

0.97 (0.49–1.90)

0.92

1.09 (0.71–1.66)

0.702

1.21 (0.79–1.85)

0.372

2.37 (1.53–3.67)

<0.001

1.58 (0.99–2.53)

0.055

Period of enrollment

1985–1991

Ref.

           

1992–1997

1.56 (1.43–1.71)

<0.001

          

1998–2003

1.29 (1.16–1.43)

<0.001

          

2004–2009

1.14 (1.02–1.28)

0.026

          

2010–2013

1.17 (1.01–1.35)

0.032

          
  1. The associations of demographical and clinical features with late presentation were investigated using a logistic regression model, providing estimates of the odds ratios (ORs) as measures of association. Separate analyses have been performed in different time periods. 95 % CI 95 % confidence interval, OR odds ratio. Ref reference category
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BMC Public Health

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