Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) – a Pan Canadian cohort study

Table 7 Power of given sample size between 6400 and 7400 participants recruited to detect expected hazard ratios

Exposure	Assumed prevalence of exposure	Outcome	Assumed incidence of Ooutcome	Expected hazard ratio	7000/ (5920)¹	6000 /(5120)¹	5000/(4320)
Regional Wall Motion Abnormality	0.253	CVD	0.0598	2.60	>0.99/>0.99	>0.99/0.99	>0.99/>0.99
Silent Stroke	0.069	CVD	0.0598	2.85	>0.99	>0.99	>0.99
Liver Fat^a	0.063	T2DM	0.0974–0.1275	1.60	0.82	0.76	0.68

¹ Assuming 20 % of the participants will have existing CVD the Number of Participants free of CVD and Cancer are shown in parenthesis; ^a (assuming a higher proportion of First Nations participants are retained, relative to other groups)

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