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Table 4 Extended MRI Scan Protocol

From: Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) – a Pan Canadian cohort study

Extended
Sequence Approximate Imaging Time (min) Outcome Measure
Cardiac
 Cine SSFP (3 long axis views and 10–15 short axis views) 12 LV global (EF) and regional wall motion abnormalities function
LV mass index
LV end-systolic volume index
LV mass-to-volume ratio
LA size and function
Circumferential strain
RV volume and global function
 Phase-contrast cine 4 Aortic elasticity
 LGE 12 Myocardial fibrosis
 T1 Mapping 10 Diffuse fibrosis
 T2 star-weighted sensitive sequence 10 Microvascular function
Brain
 3D T1w MPRAGE 8 Brain Volume
 PD/T2 4 Covert stroke and white matter lesion burden
 T2 star-weighted gradient echo sequence 4 Presence of microbleeds
 2D resting state fMRI 4 Functional connectivity
 3D arterial spin labeling (ASL) 7 Cerebral blood flow
 2D diffusion tensor imaging (DTI) 5 White matter connectivity
Abdomen
 T1w TSE abdominal adipose tissue sequence 2 Visceral fat area
 Liver 2D multi-echo gradient-echo sequence 1 Liver fat %
Cerebrovascular
 3D T1w MPRAGE 8 Plaque volume and intraplaque hemorrhage detection
 TOF 6 Plaque volume and intraplaque hemorrhage detection
 3D T1w MPRAGE + contrast 5 Lipid core, calcification inflammation/angiogenesis
Additional time for positioning
 Coil Positioning 6  
 Biobreak 10  
 Total time 118