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Table 4 Extended MRI Scan Protocol

From: Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) – a Pan Canadian cohort study

Extended

Sequence

Approximate Imaging Time (min)

Outcome Measure

Cardiac

 Cine SSFP (3 long axis views and 10–15 short axis views)

12

LV global (EF) and regional wall motion abnormalities function

LV mass index

LV end-systolic volume index

LV mass-to-volume ratio

LA size and function

Circumferential strain

RV volume and global function

 Phase-contrast cine

4

Aortic elasticity

 LGE

12

Myocardial fibrosis

 T1 Mapping

10

Diffuse fibrosis

 T2 star-weighted sensitive sequence

10

Microvascular function

Brain

 3D T1w MPRAGE

8

Brain Volume

 PD/T2

4

Covert stroke and white matter lesion burden

 T2 star-weighted gradient echo sequence

4

Presence of microbleeds

 2D resting state fMRI

4

Functional connectivity

 3D arterial spin labeling (ASL)

7

Cerebral blood flow

 2D diffusion tensor imaging (DTI)

5

White matter connectivity

Abdomen

 T1w TSE abdominal adipose tissue sequence

2

Visceral fat area

 Liver 2D multi-echo gradient-echo sequence

1

Liver fat %

Cerebrovascular

 3D T1w MPRAGE

8

Plaque volume and intraplaque hemorrhage detection

 TOF

6

Plaque volume and intraplaque hemorrhage detection

 3D T1w MPRAGE + contrast

5

Lipid core, calcification inflammation/angiogenesis

Additional time for positioning

 Coil Positioning

6

 

 Biobreak

10

 

 Total time

118