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Table 6 Blood biomarker concentration summary and statistical comparisons

From: Reductions in biomarkers of exposure, impacts on smoking urge and assessment of product use and tolerability in adult smokers following partial or complete substitution of cigarettes with electronic cigarettes

  Exclusive e-Cigarette use groups Dual use groups Nicotine cessation
N = 13
Biomarker Tobacco rechargeable
N = 15
Cherry rechargeable
N = 13
Cherry disposable
N = 13
Tobacco rechargeable
N = 14
Cherry rechargeable
N = 15
Cherry disposable
N = 13
Blood COHb (%)       
 Day −1 6.3 ± 2.0 6.3 ± 2.0 6.0 ± 1.5 5.2 ± 2.0 4.8 ± 1.4 5.6 ± 1.9 7.4 ± 2.3
Day 5 1.2 ± 0.6 1.2 ± 0.5 1.0 ± 0.6 4.0 ± 1.5 3.8 ± 0.9 4.3 ± 1.3 1.6 ± 0.4
 p-value Day −1 vs Day 5 0.0001 <0.0001 <0.0001 0.0179 0.0775 0.0170 0.0001
 p-value Day 5 vs Cessation 0.5011 0.6009 0.4794 <0.0001 <0.0001 <0.0001 NA
Plasma Nicotine (ng/mL)       
 Day −1 13.0 ± 6.1 14.7 ± 5.2 13.3 ± 6.5 12.5 ± 5.9 8.8 ± 3.2 11.1 ± 4.1 16.0 ± 7.0
 Day 5 6.9 ± 6.3 8.4 ± 5.9 6.6 ± 5.6 9.5 ± 6.2 8.1 ± 5.2 7.9 ± 4.4 0.1 ± 0.0
 p-value Day −1 vs Day 5 0.0033 0.0035 0.0053 0.0518 0.6197 0.0112 <0.0001
 p-value Day 5 vs Cessation <0.0001 <0.0001 0.0002 <0.0001 <0.0001 <0.0001 NA
Plasma Cotinine (ng/mL)       
 Day −1 260.1 ± 128.1 299.9 ± 93.7 250.1 ± 92.4 247.6 ± 99.0 213.6 ± 62.8 218.4 ± 58.3 282.2 ± 135.9
 Day 5 164.5 ± 167.4 202.1 ± 103.2 149.2 ± 116.1 261.5 ± 119.4 211.5 ± 70.2 212.9 ± 89.3 5.49 ± 6.7
 p-value Day −1 vs Day 5 0.0438 0.0160 0.0112 0.6554 0.8935 0.7474 <0.0001
 p-value Day 5 vs Cessation <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 NA
Plasma Trans-3′hydroxycotinine (ng/mL)      
 Day −1 164.5 ± 167.4 202.1 ± 103.2 149.2 ± 116.1 261.5 ± 119.4 211.5 ± 70.2 212.9 ± 89.3 5.49 ± 6.7
 Day 5 70.4 ± 59.0 85.0 ± 55.7 69.4 ± 56.5 102.2 ± 46.8 107.8 ± 50.7 98.5 ± 29.3 3.8 ± 2.7
 p-value Day −1 vs Day 5 0.1626 0.3316 0.2073 0.0821 0.0051 0.1082 <0.0001
 p-value Day 5 vs Cessation <0.0001 <0.0001 0.0002 <0.0001 <0.0001 <0.0001 NA
  1. Values are presented as mean ± SD