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Table 6 Blood biomarker concentration summary and statistical comparisons

From: Reductions in biomarkers of exposure, impacts on smoking urge and assessment of product use and tolerability in adult smokers following partial or complete substitution of cigarettes with electronic cigarettes

 

Exclusive e-Cigarette use groups

Dual use groups

Nicotine cessation

N = 13

Biomarker

Tobacco rechargeable

N = 15

Cherry rechargeable

N = 13

Cherry disposable

N = 13

Tobacco rechargeable

N = 14

Cherry rechargeable

N = 15

Cherry disposable

N = 13

Blood COHb (%)

      

 Day −1

6.3 ± 2.0

6.3 ± 2.0

6.0 ± 1.5

5.2 ± 2.0

4.8 ± 1.4

5.6 ± 1.9

7.4 ± 2.3

Day 5

1.2 ± 0.6

1.2 ± 0.5

1.0 ± 0.6

4.0 ± 1.5

3.8 ± 0.9

4.3 ± 1.3

1.6 ± 0.4

 p-value Day −1 vs Day 5

0.0001

<0.0001

<0.0001

0.0179

0.0775

0.0170

0.0001

 p-value Day 5 vs Cessation

0.5011

0.6009

0.4794

<0.0001

<0.0001

<0.0001

NA

Plasma Nicotine (ng/mL)

      

 Day −1

13.0 ± 6.1

14.7 ± 5.2

13.3 ± 6.5

12.5 ± 5.9

8.8 ± 3.2

11.1 ± 4.1

16.0 ± 7.0

 Day 5

6.9 ± 6.3

8.4 ± 5.9

6.6 ± 5.6

9.5 ± 6.2

8.1 ± 5.2

7.9 ± 4.4

0.1 ± 0.0

 p-value Day −1 vs Day 5

0.0033

0.0035

0.0053

0.0518

0.6197

0.0112

<0.0001

 p-value Day 5 vs Cessation

<0.0001

<0.0001

0.0002

<0.0001

<0.0001

<0.0001

NA

Plasma Cotinine (ng/mL)

      

 Day −1

260.1 ± 128.1

299.9 ± 93.7

250.1 ± 92.4

247.6 ± 99.0

213.6 ± 62.8

218.4 ± 58.3

282.2 ± 135.9

 Day 5

164.5 ± 167.4

202.1 ± 103.2

149.2 ± 116.1

261.5 ± 119.4

211.5 ± 70.2

212.9 ± 89.3

5.49 ± 6.7

 p-value Day −1 vs Day 5

0.0438

0.0160

0.0112

0.6554

0.8935

0.7474

<0.0001

 p-value Day 5 vs Cessation

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

NA

Plasma Trans-3′hydroxycotinine (ng/mL)

     

 Day −1

164.5 ± 167.4

202.1 ± 103.2

149.2 ± 116.1

261.5 ± 119.4

211.5 ± 70.2

212.9 ± 89.3

5.49 ± 6.7

 Day 5

70.4 ± 59.0

85.0 ± 55.7

69.4 ± 56.5

102.2 ± 46.8

107.8 ± 50.7

98.5 ± 29.3

3.8 ± 2.7

 p-value Day −1 vs Day 5

0.1626

0.3316

0.2073

0.0821

0.0051

0.1082

<0.0001

 p-value Day 5 vs Cessation

<0.0001

<0.0001

0.0002

<0.0001

<0.0001

<0.0001

NA

  1. Values are presented as mean ± SD
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BMC Public Health

ISSN: 1471-2458

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