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Table 4 Statistical comparisons of the Day 5 estimated nicotine delivered by e-Cigarettes between use groups

From: Reductions in biomarkers of exposure, impacts on smoking urge and assessment of product use and tolerability in adult smokers following partial or complete substitution of cigarettes with electronic cigarettes

Comparison First LSM (mg) Second LSM (mg) Difference (mg) p-Value
A1 vs B1 19.40 12.74 6.66 0.2140
A2 vs B2 22.86 7.04 15.83 0.0038
A3 vs B3 22.91 9.08 13.83 0.0125
A1 vs A2 19.40 22.86 −3.46 0.5170
A1 vs A3 19.40 22.91 −3.51 0.5117
A2 vs A3 22.86 22.91 −0.04 0.9934
B1 vs B2 12.74 7.04 5.70 0.2873
B1 vs B3 12.74 9.08 3.66 0.5011
B2 vs B3 7.04 9.08 −2.04 0.7074
  1. LSM Least-square means
  2. Use Groups
  3. A1: Exclusive Tobacco flavor rechargeable e-cigarette
  4. A2: Exclusive Cherry flavor rechargeable e-cigarette
  5. A3: Exclusive Cherry flavor disposable e-cigarette
  6. B1: Dual Tobacco flavor rechargeable e-cigarette and usual brand combustible cigarette
  7. B2: Dual Cherry flavor rechargeable e-cigarette and usual brand combustible cigarette
  8. B3: Dual Cherry flavor disposable e-cigarette and usual brand combustible cigarette
  9. p-values indicate statistically significant