Reductions in biomarkers of exposure, impacts on smoking urge and assessment of product use and tolerability in adult smokers following partial or complete substitution of cigarettes with electronic cigarettes

Table 4 Statistical comparisons of the Day 5 estimated nicotine delivered by e-Cigarettes between use groups

Comparison	First LSM (mg)	Second LSM (mg)	Difference (mg)	p-Value
A1 vs B1	19.40	12.74	6.66	0.2140
A2 vs B2	22.86	7.04	15.83	*0.0038*
A3 vs B3	22.91	9.08	13.83	*0.0125*
A1 vs A2	19.40	22.86	−3.46	0.5170
A1 vs A3	19.40	22.91	−3.51	0.5117
A2 vs A3	22.86	22.91	−0.04	0.9934
B1 vs B2	12.74	7.04	5.70	0.2873
B1 vs B3	12.74	9.08	3.66	0.5011
B2 vs B3	7.04	9.08	−2.04	0.7074

LSM Least-square means
Use Groups
A1: Exclusive Tobacco flavor rechargeable e-cigarette
A2: Exclusive Cherry flavor rechargeable e-cigarette
A3: Exclusive Cherry flavor disposable e-cigarette
B1: Dual Tobacco flavor rechargeable e-cigarette and usual brand combustible cigarette
B2: Dual Cherry flavor rechargeable e-cigarette and usual brand combustible cigarette
B3: Dual Cherry flavor disposable e-cigarette and usual brand combustible cigarette
p-values indicate statistically significant

ISSN: 1471-2458