Association between depressive symptoms, use of antidepressant medication and the metabolic syndrome: the Maine-Syracuse Study

Table 4 Odds of having individual metabolic syndrome components according to use of antidepressant medications in the Maine-Syracuse Longitudinal Study

Predictor	Covariate set^a	Group	MetS elevated glucose^b			MetS hypertension^b			MetS low HDL-cholesterol^b
			OR	95 % CI	P	OR	95 % CI	P	OR	95 % CI	P
Antidepressant medication use	Basic	Yes	2.01	1.30, 3.13	0.002	1.99	1.21, 3.25	0.006	1.66	1.10, 2.51	0.015
Antidepressant medication use		No	1.00			1.00			1.00
	Extended	Yes	1.95	1.23, 3.09	0.005	1.81	1.09, 3.02	0.023	1.57	1.03, 2.40	0.036
		No	1.00			1.00			1.00

CI, confidence interval; MetS, metabolic syndrome; OR, odds ratio
^aBasic: adjusted for age, education, sex, ethnicity; Extended: adjusted for set 1 + smoking (cigarettes per day), physical activity (MET-minutes/day), CRP (mg/L)
^bMetS clinical cut off points: elevated fasting plasma glucose: ≥5.6 mmol/L or ≥100 mg/dL; elevated blood pressure: systolic: ≥130 and/or diastolic ≥85 mmHg; reduced HDL-cholesterol: <1.0 mmol/L or <40 mg/dL for males; <1.3 mmol/L or <50 mg/dL for females [1]