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Table 4 Association between parental smoking during pregnancy and risk of asthma at any time among offspring in married families

From: Parental smoking and cessation during pregnancy and the risk of childhood asthma

 

No asthma N = 23427

Asthma N = 1741

Asthma prevalence (%)

aOR*95%CI

p-value**

No maternal smoking

Paternal non-smokera

14227 (60.7)

1040 (59.7)

6.8

1

 

Paternal recent quitterb

1228 (5.2)

64 (3.7)

5.0

0.30 (0.2-0.4)

<0.001

Paternal smoking

2967 (12.7)

251 (14.4)

7.8

3.01 (2.6-3.7)

<.0.001

Maternal recent quitterb

Paternal non-smokera

679 (2.9)

51 (2.9)

7.8

1.12 (0.8-1.5)

0.0483

Paternal recent quitterb

528 (2.3)

35 (2.0)

6.2

0.50 (0.3-0.7)

<0.001

Paternal smoking

1008 (4.3)

87 (5.0)

7.9

2.71 (2.1-3.5)

<.0.001

Maternal smoking

Paternal non-smokera

323 (1.4)

27 (1.6)

7.7

1.59 (1.0-2.5)

0.042

Paternal recent quitterb

280 (1.2)

13 (0.7)

4.4

0.22 (0.1-0.4)

<0.001

Paternal smoking

966 (4.1)

101 (5.8)

9.5

3.94 (3.1-5.1)

<0.001

Missing data

1221 (5.2)

72 (4.1)

5.6

  
  1. aNo smoking before or during pregnancy
  2. bQuit smoking prior to or during pregnancy
  3. *Adjusted for the following maternal factors at birth: asthma, age, parity, pre-pregnancy BMI and ART, plus gender of child, gestational weeks at birth, mode of delivery and age of asthma or among controls follow-up time
  4. **p-value for adjusted analysis obtained from the trend test (Wald) in logistic regression model