Table 2 Association between vaccination and mumps complications or hospitalization, vaccine effectiveness, Czech Republic, 2007–2012
From: Protective effect of vaccination against mumps complications, Czech Republic, 2007–2012
Type of complication | VACCINATION number of dosesb | MUMPS number of cases | COMPLICATIONS number of cases (%) | Unadjusted odds ratio (95 % CI) | Adjustedc odds ratio (95 % CI) | P value | Adjustedc vaccine effectiveness % (95 % CI) |
|---|---|---|---|---|---|---|---|
Any complication | 0 | 1662 | 430 (25.9) | Ref | Ref | ||
1 | 71 | 4 (5.6) | 0.17 (0.06, 0.47) | 0.32 (0.11, 0.91) | 0.033 | 68 (9, 89) | |
2 | 7907 | 516 (6.5) | 0.20 (0.17, 0.23) | 0.32 (0.25, 0.39) | <0.001 | 68 (61, 75) | |
Orchitisa | 0 | 1006 | 322 (32.0) | Ref | Ref | ||
1 | 33 | 3 (9.1) | 0.21 (0.06, 0.70) | 0.34 (0.10, 1.16) | 0.086 | 66 (-16, 10) | |
2 | 4548 | 333 (7.3) | 0.17 (0.14, 0.20) | 0.28 (0.22, 0.36) | <0.001 | 72 (64, 78) | |
Meningitis | 0 | 1662 | 66 (4.0) | Ref | Ref | ||
1 | 71 | 1 (1.4) | 0.35 (0.05, 2.52) | 0.50 (0.07, 3.80) | 0.502 | 50 (-280, 93) | |
2 | 7907 | 87 (1.1) | 0.27 (0.19, 0.37) | 0.34 (0.21, 0.54) | <0.001 | 64 (46, 79) | |
Encephalitis | 0 | 1662 | 12 (0.7) | Ref | Ref | ||
1 | 71 | 0 (0.0) | |||||
2 | 7907 | 3 (0.0) | 0.05 (0.01, 0.19) | 0.07 (0.02, 0.34) | 0.001 | 93 (66, 98) | |
Pancreatitis | 0 | 1662 | 15 (0.9) | Ref | Ref | ||
1 | 71 | 0 (0.0) | |||||
2 | 7907 | 47 (0.6) | 0.66 (0.37, 1.18) | 1.18 (0.49, 2.86) | 0.706 | -18 (-186, 51) | |
Hospitalization | 0 | 1662 | 511 (30.7) | Ref | Ref | ||
(males + females) | 1 | 71 | 6 (8.5) | 0.21 (0.09, 0.48) | 0.32 (0.13, 0.76) | 0.010 | 68 (24, 87) |
2 | 7907 | 673 (8.5) | 0.21 (0.18, 0.24) | 0.29 (0.24, 0.35) | <0.001 | 71 (65, 76) | |
Hospitalization | 0 | 1006 | 417 (41.5) | Ref | Ref | ||
(males onlya) | 1 | 33 | 4 (12.1) | 0.19 (0.07, 0.56) | 0.30 (0.10, 0.89) | 0.030 | 41 (11, 90) |
2 | 4548 | 502 (11.0) | 0.18 (0.15, 0.20) | 0.26 (0.21, 0.33) | <0.001 | 74 (67, 79) |