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Table 4 PPV of the test, standardized participation, lesion and colonoscopy following positive test result, by socioeconomic stratum of place of residence

From: Social inequalities in a population based colorectal cancer screening programme in the Basque Country

Women

Men

DI quintile

successfully-invited population

no. of participants

% participation

OR

(95 % CI)

DI quintile

successfully-invited population

no. of participants

% participation

OR

(95 % CI)

I (least disadvantaged)

26193

17228

65.73

1.00

 

I (least disadvantaged)

23947

14743

61.87

1.00

 

II

24373

17026

69.89

1.21

(1.16-1.25)

II

23373

15079

64.91

1.14

(1.10-1.19)

III

22632

16160

71.46

1.30

(1.25-1.35)

III

21440

14086

66.07

1.20

(1.15-1.25)

IV

19927

13819

69.30

1.17

(1.13-1.22)

IV

19343

12349

64.07

1.10

(1.06-1.14)

V (most disadvantaged)

19409

12820

66.06

1.01

(0.97-1.05)

V (most disadvantaged)

18483

11069

60.25

0.93

(0.90-0.97)

    

p < 0.001

     

p < 0.001

 

DI quintile

no. of participants

no. of lesions (premal. + malignant)

rate of lesions (premal. + malignant) among participantsa

OR

(95 % CI)

DI quintile

no. of participants

no. of lesions (premal. + malignant)

rate of lesions (premal. + malignant) among participants

OR

(95 % CI)

I (least disadvantaged)

17228

255

15.39

1.00

 

I (least disadvantaged)

14743

594

40.99

1.00

 

II

17026

246

14.61

0.97

(0.81-1.16)

II

15079

705

48.73

1.18

(1.06-1.32)

III

16160

258

16.12

1.07

(0.90-1.27)

III

14086

703

50.76

1.25

(1.12-1.40)

IV

13819

233

16.99

1.11

(0.93-1.33)

IV

12349

617

49.83

1.23

(1.10-1.38)

V (most disadvantaged)

12820

197

15.40

1.01

(0.84-1.22)

V (most disadvantaged)

11069

608

55.68

1.38

(1.23-1.55)

    

p = 0.600

     

p = 0.002

RII 1.37 (1.21-1-55)

DI quintile

no. of participants

no. of malignant lesions

rate of malignant lesions among participantsa

OR

(95 % CI)

DI quintile

no. of participants

no. of malignant lesions

rate of malignant lesions among participants

OR

(95 % CI)

I (least disadvantaged)

17228

38

2,25

1,00

 

I (least disadvantaged)

14743

78

5,46

1,00

 

II

17026

37

2,24

0,98

(0.62-1.54)

II

15079

85

6,14

1,08

(0.80-1.48)

III

16160

38

2,37

1,05

(0.67-1.65)

III

14086

93

6,89

1,25

(0.92-1.69)

IV

13819

31

2,35

0,97

(0.60-1.56)

IV

12349

45

3,60

0,66

(0.45-0.95)

V (most disadvantaged)

12820

37

2,90

1,25

(0.79-1.97)

V (most disadvantaged)

11069

68

6,37

1,14

(0.82-1.58)

    

p = 0.824

     

p = 0.006

 

DI quintile

no. of participants

no. of carcinomas stage III/IV

no. of carcinomas stage III/IV

OR

(95 % CI)

DI quintile

no. of participants

no. of carcinomas stage III/IV

no. of carcinomas stage III/IV

OR

(95 % CI)

I (least disadvantaged)

17228

10

0.70

1.00

 

I (least disadvantaged)

14743

24

1.97

1.00

 

II

17026

14

0.84

1.27

(0.59-2.76)

II

15079

27

2.03

1.00

(0.59-1.69)

III

16160

10

0.67

0.97

(0.42-2.22)

III

14086

20

1.52

0.75

(0.41-1.32)

IV

13819

12

0.89

1.23

(0.54-2.76)

IV

12349

12

0.94

0.49

(0.24-0.93)

V (most disadvantaged)

12820

13

0.99

1.44

(0.65-3.20)

V (most disadvantaged)

11069

22

2.13

1.02

(0.58-1.77)

    

p = 0.853

     

p = 0.137

 

DI quintile

people with + FOBT

people who had colonoscopy

% colonoscopies

OR

(95 % CI)

DI quintile

people with + FOBT

people who had colonoscopy

% colonoscopies

OR

(95 % CI)

I (least disadvantaged)

773

688

89.07

1.00

 

I (least disadvantaged)

1168

1056

90.51

1.00

 

II

789

723

91.64

1.34

(0.96-1.89)

II

1295

1205

92.96

1.41

(1.06-1.89)

III

735

685

93.45

1.68

(1.17-2.44)

III

1292

1227

94.89

2.01

(1.47-2.77)

IV

688

647

93.99

1.94

(1.32-2.88)

IV

1154

1102

95.60

2.25

(1.61-3.18)

V (most disadvantaged)

665

622

93.65

1.78

(1.22-2.63)

V (most disadvantaged)

1119

1037

92.51

1.33

(0.99-1.80)

    

p = 0.003

     

p = <0.001

 

DI quintile

people who had colonoscopy

no. of lesions (premal. + malignant)

% lesions found in colonoscopy

OR

(95 % CI)

DI quintile

people who had colonoscopy

no. of lesions (premal. + malignant)

% lesions found in colonoscopy

OR

(95 % CI)

I (least disadvantaged)

688

255

37.01

1.00

 

I (least disadvantaged)

1056

594

55.46

1.00

 

II

723

246

33.88

0.88

(0.70-1.09)

II

1205

705

57.23

1.10

(0.93-1.30)

III

685

258

37.72

1.03

(0.82-1.27)

III

1227

703

56.27

1.05

(0.88-1.24)

IV

647

233

36.14

0.95

(0.76-1.19)

IV

1102

617

54.97

0.99

(0.83-1.17)

V (most disadvantaged)

622

197

31.01

0.79

(0.63-0.99)

V (most disadvantaged)

1037

608

57.61

1.09

(0.91-1.30)

    

p = 0.143

     

p = 0.669

 

DI quintile

people with + FOBT

no. of lesions (premal. + malignant)

PPV

OR

(95 % CI)

DI quintile

people with + FOBT

no. of lesions (premal. + malignant)

PPV

OR

(95 % CI)

I (least disadvantaged)

773

255

32.97

1.00

 

I (least disadvantaged)

1168

594

50.18

1.00

 

II

789

246

31.05

0.92

(0.74-1.14)

II

1295

705

53.25

1.16

(0.99-1.36)

III

735

258

35.26

1.10

(0.89-1.36)

III

1292

703

53.49

1.16

(0.99-1.36)

IV

688

233

33.98

1.04

(0.83-1.29)

IV

1154

617

52.57

1.11

(0.94-1.31)

V (most disadvantaged)

665

197

29.00

0.85

(0.68-1.07)

V (most disadvantaged)

1119

608

53.29

1.14

(0.96-1.34)

    

p = 0.197

     

p = 0.349

 
  1. OR Age-adjusted odds ratios, CI Confidence interval
  2. DI quintile: Socioeconomic deprivation index quintile proposed by the MEDEA project; p: significance value of the likelihood ratio test for the association between DI and outcome variable; RII: relative index of inequality
  3. aage-standardized rates per 1000 inhabitants (reference population Basque Country 2011)