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Table 4 Summary of change in smoking urge parameters and statistical comparisons to the tobacco cigarette

From: Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes

  E-Cigarettes  
Smoking Urge Parameters 2.4 % nic + Gly 2.4 % nic + Gly/PG 2.4 % nic + Gly + menthol 1.6 % nic + Gly 1.6 % nic + Gly/PG Tobacco Cigarette
N = 23 N = 23 N = 23 N = 23 N = 23 N = 24
Emax0–30 (mm) −41.9 ± 26.56 −44.7 ± 26.98 −37.0 ± 30.25 −40.2 ± 32.47 −40.7 ± 24.25 −41.5 ± 27.43
p-value 0.9285 0.6427 0.3023 0.6972 0.7450  
Emaxreduction0–30 (mm) −42.2 ± 26.01 −44.7 ± 26.98 −39.1 ± 25.86 −41.4 ± 30.40 −40.7 ± 24.25 −41.7 ± 27.08
p-value 0.9489 0.6505 0.5056 0.8480 0.7079  
AUEC0–30 (hr*mm) −14.1 ± 10.56 −15.5 ± 10.39 −12.2 ± 10.75 −13.9 ± 12.09 −13.3 ± 8.29 −15.4 ± 12.67
p-value 0.4054 0.8912 0.0882 0.3590 0.2225  
TEmax0–30 (hr) 0.41 (0.07, 0.50) 0.41 (0.07, 0.50) 0.41 (0.08, 0.50) 0.42 (0.08, 0.50) 0.49 (0.24, 0.50) 0.25 (0.07, 0.51)
p-value 0.1764 0.0948 0.0014 0.0012 0.0009  
AUEC30–90 (hr*mm) −44.3 ± 35.39 −50.9 ± 33.64 −42.7 ± 38.24 −46.2 ± 40.23 −47.7 ± 34.16 −46.9 ± 30.14
p-value 0.6679 0.5275 0.5046 0.8919 0.9395  
E90 (mm) −37.0 ± 30.69 −42.5 ± 29.85 −34.3 ± 34.03 −37.4 ± 35.08 −38.5 ± 30.12 −52.2 ± 26.33
p-value 0.0060 0.0921 0.0010 0.0066 0.0122  
  1. TEmax0–30 is presented as median (minimum, maximum), all other values are presented as arithmetic mean ± SD. Statistical significance is based on the differences in least squares means between groups. P-values represent the comparison to the tobacco cigarette
  2. nic nicotine, Gly glycerine, PG propylene glycol