Skip to main content

Table 3 Summary of plasma nicotine pharmacokinetic parameters and statistical comparisons to the tobacco cigarette

From: Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes

  E-Cigarettes  
Pharmacokinetic Parameters 2.4 % nic + Gly 2.4 % nic + Gly/PG 2.4 % nic + Gly + menthol 1.6 % nic + Gly 1.6 % nic + Gly/PG Tobacco Cigarette
N = 23 N = 23 N = 23 N = 23 N = 23 N = 24
Cmax0–30 (ng/mL) 17.4 ± 5.97 18.1 ± 6.47 15.3 ± 5.16 10.3 ± 3.70* 15.1 ± 4.61 15.8 ± 8.64
p-value 0.1242 0.0508 0.8858 0.0002 0.7776  
Tmax0–30 (hr) 0.50 (0.33, 0.55) 0.50 (0.33, 0.52) 0.50 (0.33, 0.52) 0.50 (0.33, 0.61) 0.50 (0.33, 0.62) 0.09 (0.08, 0.42)
p-value <0.0001 <0.0001 <0.0001 <0.0001 <0.0001  
AUC0–30 (ng*hr/mL) 4.7 ± 1.84 4.9 ± 1.75 4.1 ± 1.63 3.0 ± 1.18 4.3 ± 1.39 4.9 ± 1.79
p-value 0.7636 0.8443 0.0406 <0.0001 0.0928  
AUC30–90 (ng*hr/mL) 22.4 ± 5.61 24.6 ± 7.99 21.6 ± 5.08 14.7 ± 5.15 19.8 ± 4.72 22.1 ± 5.98
p-value 0.8463 0.0602 0.6319 <0.0001 0.0756  
C90 (ng/mL) 19.7 ± 5.72 22.4 ± 7.65 19.4 ± 5.80 13.7 ± 5.98 16.8 ± 4.44 29.2 ± 10.86
p-value <0.0001 <0.0001 <0.0001 <0.0001 <0.0001  
  1. Tmax0–30 is presented as median (minimum, maximum), all other values are presented as arithmetic mean ± SD. Statistical significance is based on the differences in least squares means between groups. P-values represent the comparison to the tobacco cigarette
  2. nic nicotine, Gly glycerine, PG propylene glycol