Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes

Table 3 Summary of plasma nicotine pharmacokinetic parameters and statistical comparisons to the tobacco cigarette

	E-Cigarettes
Pharmacokinetic Parameters	2.4 % nic + Gly	2.4 % nic + Gly/PG	2.4 % nic + Gly + menthol	1.6 % nic + Gly	1.6 % nic + Gly/PG	Tobacco Cigarette
Pharmacokinetic Parameters	N = 23	N = 23	N = 23	N = 23	N = 23	N = 24
C_max0–30 (ng/mL)	17.4 ± 5.97	18.1 ± 6.47	15.3 ± 5.16	10.3 ± 3.70*	15.1 ± 4.61	15.8 ± 8.64
p-value	0.1242	0.0508	0.8858	0.0002	0.7776
T_max0–30 (hr)	0.50 (0.33, 0.55)	0.50 (0.33, 0.52)	0.50 (0.33, 0.52)	0.50 (0.33, 0.61)	0.50 (0.33, 0.62)	0.09 (0.08, 0.42)
p-value	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
AUC_0–30 (ng*hr/mL)	4.7 ± 1.84	4.9 ± 1.75	4.1 ± 1.63	3.0 ± 1.18	4.3 ± 1.39	4.9 ± 1.79
p-value	0.7636	0.8443	0.0406	<0.0001	0.0928
AUC_30–90 (ng*hr/mL)	22.4 ± 5.61	24.6 ± 7.99	21.6 ± 5.08	14.7 ± 5.15	19.8 ± 4.72	22.1 ± 5.98
p-value	0.8463	0.0602	0.6319	<0.0001	0.0756
C₉₀ (ng/mL)	19.7 ± 5.72	22.4 ± 7.65	19.4 ± 5.80	13.7 ± 5.98	16.8 ± 4.44	29.2 ± 10.86
p-value	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001

T_max0–30 is presented as median (minimum, maximum), all other values are presented as arithmetic mean ± SD. Statistical significance is based on the differences in least squares means between groups. P-values represent the comparison to the tobacco cigarette
nic nicotine, Gly glycerine, PG propylene glycol

ISSN: 1471-2458