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Table 3 Preferred term within system organ classification of reported adverse events of 228 exposed HCWs/HCSs on HIV post-exposure prophylaxis

From: Adverse events and adherence to HIV post-exposure prophylaxis: a cohort study at the Korle-Bu Teaching Hospital in Accra, Ghana

Number of adverse events reported by preferred term within system organ classification (n, %1) Total 3TC/AZT-3 days 3TC/AZT-28 days 33TC/AZT/LPV-RTV-28 days
N = 228 N = 101 N = 75 N = 52
n, %1, 2 n, %1, 2 n, %1, 2
Gastrointestinal (n = 122, 53.5)     
Nausea 101 (44.3) 17 (16.8) 47 (62.7) 37 (71.2)
Diarrhoea 38 (16.7) 3 (3.0) 1 (1.3) 34 (65.4)
Vomiting 24 (10.5) 1 (1.0) 5 (6.7) 18 (34.6)
Loss of appetite 14 (6.1) 3 (3.0) 6 (8.0) 5 (9.6)
Abdominal pains 14 (6.1) 2 (2.0) 5 (6.7) 7 (13.5)
Anorexia 5 (2.2) - 2 (2.7) 3 (5.8)
Dehydration 1 (0.4) - 1 (1.3) -
Bitter mouth 1 (0.4) 1 (1.0) - -
Constipation 1 (0.4) - 1 (1.3) -
Excessive flatulence 1 (0.4) - - 1 (1.9)
Abdominal discomfort 1 (0.4) - 1 (1.3) -
Hyper-salivation 1 (0.4) - - 1 (1.9)
Sore throat 1 (0.4) - - 1 (1.9)
Excessive spitting 1 (0.4) - 1 (1.3) -
Hunger pain 1 (0.4) - 1 (1.3) -
Systematic signs & symptoms (n = 106, 46.5)     
Weakness 54 (23.7) 10 (9.9) 28 (37.3) 16 (30.8)
Malaise 37 (16.2) 6 (5.9) 17 (22.7) 14 (26.9)
Dizziness 30 (13.2) 6 (5.9) 20 (26.7) 4 (7.7)
Fatigue 28 (12.3) 2 (2.0) 21 (28.0) 5 (9.6)
Feverish 5 (2.2) - 2 (2.7) 3 (5.8)
General body pains 2 (0.9) - 2 (2.7) -
Neurological system (n = 42, 18.4)     
Headache 27 (11.8) 3 (3.0) 19 (25.3) 5 (9.6)
Restlessness 8 (3.5) 2 (2.0) 4 (5.3) 2 (3.8)
Insomnia 7 (3.1) 1 (1.0) 4 (5.3) 2 (3.8)
Drowsiness 5 (2.2) 1 (1.0) 1 (1.3) 3 (5.8)
Depression 1 (0.4) - 1 (1.3) -
Skin (n = 9, 3.9)     
Rashes 5 (2.2) 2 (2.0) 2 (2.7) 1 (1.9)
Itching 2 (0.9) 2 (2.0) - -
Alopecia 1 (0.4) - 1 (1.3) -
Dark pigmentation of finger & toe nails 1 (0.4) - - 1 (1.9)
Central/peripheral nervous system (n = 4, 1.8)     
Eye pain 1 (0.4) - 1 (1.3) -
Leg pains 1 (0.4) - 1 (1.3) -
Neck pains 1 (0.4) - - 1 (1.9)
Pain in feet 1 (0.4) - - 1 (1.9)
Red eye 1 (0.4) - - 1 (1.9)
Hepatitis (n = 2, 0.9)     
Yellow eyes 1 (0.4) - 1 (1.3) -
Jaundice 1 (0.4) - - 1 (1.9)
Cardiac (n = 1, 0.4)     
Tightness in chest 1 (0.4) - 1 (1.3) -
Reproductive/gynaecological (n = 1, 0.4)     
Spontaneous abortion 1 (0.4) - - 1 (1.9)
Bleeding 1 (0.4) - - 1 (1.9)
  1. 1Percentages may add up to >100
  2. 2% are percentages within each drug column; 3TC = lamivudine; AZT = zidovudine; LPV-RTV = lopinavir-ritonavir
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