Systematic review of models assessing the economic value of routine varicella and herpes zoster vaccination in high-income countries

Damm, Oliver; Ultsch, Bernhard; Horn, Johannes; Mikolajczyk, Rafael T.; Greiner, Wolfgang; Wichmann, Ole

doi:10.1186/s12889-015-1861-8

Table 6 Economic results of the models evaluating HZ vaccination in the elderly (2010 EUR, German price level)

From: Systematic review of models assessing the economic value of routine varicella and herpes zoster vaccination in high-income countries

Study	Age at vaccination (years)	Comparator	Health care payer perspective	Societal perspective
Annemans et al. [65]	50+	No vaccination	EUR 6,624/QALY; EUR 1,046/HZ case avoided; EUR 3,495-3,523/PHN case avoided^a	EUR 6,822/QALY; EUR 1,077/HZ case avoided; EUR 3,600-3,629/PHN case avoided^a
	60+	No vaccination	EUR 6,809/QALY; EUR 1,310/HZ case avoided; EUR 3,942-3,969/PHN case avoided^a	EUR 7,148/QALY; EUR 1,375/HZ case avoided; EUR 4,039-4,137/PHN case avoided^a
	65+	No vaccination	EUR 7,184/QALY; EUR 1,560/HZ case avoided; EUR 4,176-4,336/PHN case avoided^a	EUR 7,577/QALY; EUR 1,645/HZ case avoided; EUR 4,404-4,574/PHN case avoided^a
	60-64	No vaccination	EUR 5,694/QALY; EUR 817/HZ case avoided; EUR 2,936-2,969/PHN case avoided^a	EUR 5,867/QALY; EUR 842/HZ case avoided; EUR 3,025-3,059/PHN case avoided^a
	65-69	No vaccination	EUR 5,412/QALY; EUR 873/HZ case avoided; EUR 2,967-2,991/PHN case avoided^a	EUR 5,628/QALY; EUR 909/HZ case avoided; EUR 3,087-3,112/PHN case avoided^a
	60-69	No vaccination	EUR 5,553/QALY; EUR 844/HZ case avoided; EUR 2,951-2,980/PHN case avoided^a	EUR 5,747/QALY; EUR 874/HZ case avoided; EUR 3,054-3,085/PHN case avoided^a
Bilcke et al. [38]	60	No vaccination	EUR 1,200-46,968/QALY; EUR 584–5,148/HZ case avoided	NA
	70	No vaccination	EUR 2,200-70,496/QALY; EUR 1,239-8,603/HZ case avoided	NA
	80	No vaccination	EUR 3,824-126,793/QALY; EUR 2,867-17,353/HZ case avoided	NA
	85	No vaccination	EUR 5,272-291,240/QALY; EUR 4,451-42,164/HZ case avoided	NA
Bilcke et al. [30]	50 or 60	No vaccination	No results for a sole HZ vaccination reported; see Table 5 for results on combined varicella and HZ vaccination	NA
Bresse et al. [66]	65+	No vaccination	EUR 11,480/QALY; EUR 2,479/HZ case avoided; EUR 4,101/PHN case avoided^b	NA
Bresse et al. [66]	70-79	No vaccination	EUR 8,876/QALY; EUR 2,090/HZ case avoided; EUR 3,302/PHN case avoided^b	NA
Brisson et al. [67]	50	No vaccination	EUR 36,667/QALY	NA
	60	No vaccination	EUR 26,563/QALY	NA
	65	No vaccination	EUR 24,002/QALY	NA
	70	No vaccination	EUR 22,924/QALY	NA
	80	No vaccination	EUR 33,153/QALY	NA
de Boer et al. [40]	60	No vaccination	EUR 40,050/QALY	EUR 33,901/QALY
	65	No vaccination	EUR 34,440/QALY	EUR 33,511/QALY
	70	No vaccination	EUR 28,491/QALY	EUR 28,284/QALY
	75	No vaccination	EUR 28,506/QALY	EUR 28,506/QALY
Edmunds et al. [68]	65	No vaccination	EUR 5,435-100,700/QALY^c	NA
Hornberger et al. [28]	69	No vaccination	NA	From cost-saving up to EUR 250,470/QALY^d
Moore et al. [69]	50+	No vaccination	EUR 17,681/QALY; EUR 1,957/HZ case avoided; EUR 7,369-7,413/PHN case avoided	EUR 15,520/QALY; EUR 1,710/HZ case avoided; EUR 6,434-6,472/PHN case avoided
	50-54	No vaccination	EUR 18,041/QALY	EUR 12,488/QALY
	55-59	No vaccination	EUR 16,182/QALY	EUR 12,124/QALY
	60-64	No vaccination	EUR 14,931/QALY	EUR 12,866/QALY
	65-69	No vaccination	EUR 13,967/QALY	EUR 13,638/QALY
	70-74	No vaccination	EUR 17,814/QALY	EUR 17,814/QALY
	75-79	No vaccination	EUR 20,352/QALY	EUR 20,352/QALY
	80-84	No vaccination	EUR 27,176/QALY	EUR 27,176/QALY
	85-89	No vaccination	EUR 45,799/QALY	EUR 45,799/QALY
	90-94	No vaccination	EUR 67,522/QALY	EUR 67,522/QALY
	95-99	No vaccination	EUR 100,562/QALY	EUR 100,562/QALY
	100+	No vaccination	EUR 140,125/QALY	EUR 140,125/QALY
Najafzadeh et al. [26]	60+	No vaccination	EUR 28,314/QALY	NA
	60-74	No vaccination	EUR 24,002/QALY	NA
	75+	No vaccination	EUR 44,123/QALY	NA
Pellissier et al. [70]	60+, general population	No vaccination	EUR 16,170/QALY	EUR 14,232/QALY
Pellissier et al. [70]	60+, immunocompetent only	No vaccination	EUR 24,211/QALY	EUR 22,255/QALY
Rothberg et al. [42]	60, male	No vaccination	NA	EUR 130,097/QALY
	60, female	No vaccination	NA	EUR 81,076/QALY
	70, male	No vaccination	NA	EUR 59,794/QALY
	70, female	No vaccination	NA	EUR 39,512/QALY
	80, male	No vaccination	NA	EUR 173,224/QALY
	80, female	No vaccination	NA	EUR 111,779/QALY
Szucs et al. [71]	70-79	No vaccination	EUR 13,743/QALY; EUR 3,565/HZ case avoided; EUR 8,334/PHN case avoided	CHF 15,361/QALY; CHF 3,985/HZ case avoided; EUR 9,315/PHN case avoided
Ultsch et al. [39]	50	No vaccination	EUR 37,173/QALY; EUR 1,587/HZ case avoided; EUR 32,545/PHN case avoided	EUR 30,901/QALY; EUR 1,320/HZ case avoided; EUR 27,054/PHN case avoided
	55	No vaccination	EUR 32,480/QALY; EUR 1,518/HZ case avoided; EUR 26,194/PHN case avoided	EUR 28,244/QALY; EUR 1,320/HZ case avoided; EUR 22,777/PHN case avoided
	60	No vaccination	EUR 30,212/QALY; EUR 1,525/HZ case avoided; EUR 22,337/PHN case avoided	EUR 28,146/QALY; EUR 1,419/HZ case avoided; EUR 20,809/PHN case avoided
	65	No vaccination	EUR 30,807/QALY; EUR 1,655/HZ case avoided; EUR 20,951/PHN case avoided	EUR 29,526/QALY; EUR 1,586/HZ case avoided; EUR 20,079/PHN case avoided
	70	No vaccination	EUR 42,190/QALY; EUR 2,732/HZ case avoided; EUR 22,813/PHN case avoided	EUR 41,942/QALY; EUR 2,716/HZ case avoided; EUR 22,679/PHN case avoided
	75	No vaccination	EUR 55,171/QALY; EUR 3,939/HZ case avoided; EUR 27,396/PHN case avoided	EUR 54,940/QALY; EUR 3,923/HZ case avoided; EUR 27,281/PHN case avoided
	80	No vaccination	EUR 92,734/QALY; EUR 9,433/HZ case avoided; EUR 35,717/PHN case avoided	EUR 92,541/QALY; EUR 9,414/HZ case avoided; EUR 35,643/PHN case avoided
van Hoek et al. [72]	60	No vaccination	EUR 36,302/QALY	NA
	65	No vaccination	EUR 27,747/QALY	NA
	70	No vaccination	EUR 20,589/QALY	NA
	75	No vaccination	EUR 25,211/QALY	NA
van Hoek et al. [33]	75	No vaccination	49 % of the simulations below GBP 20,000/QALY (EUR 26,576/QALY); 96 % of the simulations below GBP 30,000/QALY (EUR 39,864/QALY)	NA
van Hoek et al. [33]	75 and 2-dose varicella vaccination of children	No vaccination	50 % of the simulations below GBP 20,000/QALY (EUR 26,576/QALY); 70 % of the simulations below GBP 30,000/QALY (EUR 39,864/QALY)	NA
van Lier et al. [41]	60	No vaccination	EUR 39,577/QALY	EUR 37,638/QALY
	65	No vaccination	EUR 30,514/QALY	EUR 30,514/QALY
	70	No vaccination	EUR 21,219/QALY	EUR 21,219/QALY
	75	No vaccination	EUR 23,779/QALY	EUR 23,779/QALY
	80	No vaccination	EUR 33,661/QALY	EUR 33,661/QALY

HZ herpes zoster; PHN post-herpetic neuralgia; QALY quality-adjusted life-year; NA not applicable
^aDepending on the duration of PHN
^bAll results from the third-party payer perspective
^cDepending on the efficacy and the duration of protection
^dDepending on vaccination costs

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