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Table 3 HZ mortality data from included studies

From: Herpes zoster-associated mortality in Europe: a systematic review

Study (ref) Country Period Age (years) Age at HZ-related death Mortality incidence/100 000 (95% CI) Case fatality rate (%) Hospital fatality rate (%) Number
Bilcke 2011 [21] Belgium 1990-2007 60-70   0.06    
70+   0.63
Gonzalez Chiappe 2010 [27] France 2000-2007 Overall 96.8% (1360; 170/year) in those aged ≥65 years 0.286 (0.244-0.328) 0.075 2.012 1 405 (176 ± 13/year)
≥65   4.36 ± 0.20  
45-54   0.031 (0–0.069) 0.007  
55-64   0.072 (0.009-0.135) 0.012  
65-74   0.236 (0.102-0.370) 0.027  
75-84   1.25 (0.90-1.60) 0.127  
85-94   7.24 (5.66-8.82) 0.672  
≥95   19.48 (11.50-27.47) 1.356 HFR: Malignancies: 4.236 (449/10 599) HIV/AIDS: 0.357 (26/7 277)
Diabetes: 1.654 (94/5 682)
Blood dyscrasias: 3.907 (82/2 099)
RA: 1.759 (38/2 160)
Malnutrition: 6.196 (64/1 033)
Organ transplant: 0.049 (1/2 023)
Ultsch 2011 [30] Germany 2007-2008 50-54 73% (n = 48) deaths in ≥80 years 0.02 (0.00-0.10) 0.003   1
55-59 0.00 NA 0   0
60-64   0.02 (0.00-0.13) 0.003   1
65-69   0.06 (0.01-0.17) 0.005   3
70-74   0.11 (0.04-0.27) 0.010   5
75-79   0.30 (0.14-0.57) 0.025   9
80-84   0.54 (0.28-0.94) 0.043   12
85-89   1.20 (0.67-1.98) 0.096   15
≥90   3.86 (2.36-5.96) 0.293   20
Overall   0.21 (0.16-0.26) 0.022   66
van Lier 2010 [31] Netherlands 2000-2007 ≥60 92% deaths occurred in ≥ 75 years 0.59 (estimated with pop ≥60 from Eurostat)    Mean 18 deaths/year (range 13–26)
de Melker 2006 [23] Netherlands 1996-2002 ≥75 97% occurred in ≥60 years 1.92 (estimated with pop ≥75 from Eurostat)    Mean 18 deaths/year (range 13 to 26)
Mesquita 2013 [28] Portugal 2000-2010 50-59 76.8 years (SD = 13.6)    1.0 17 (total)
60-69     0.4
70-79     0.8
80-89     2.9
90-99     3.8
Perez-Sola 2011 [29] Spain 2000-2006       0
Gil 2009 [24] Spain 1998-2004 50-59   0.3   3.8 156/year (mean)
60-69   0.6   3.7
70-79   1.5   4.5
≥80   3.9   7.1
Gil-Prieto 2011 [26] Spain 1998-2004 50-59     3.0*/1.1  
60-69     2.7*/1.7
≥70     5.3*/2.7
50-59     No comorbidity: 1.1
Comorbidity: 3.0
Diabetes: 3.0
COPD: 4.2
CVD: 3.7
60-69   No comorbidity: 1.7
Comorbidity: 2.7
Diabetes: 1.9
COPD: 2.7
CVD: 3.4
≥70   No comorbidity: 2.7
Comorbidity: 5.3
Diabetes: 5.0
COPD: 5.0
CVD: 5.9
Gil-Prieto 2012 [25] Spain 1997-2008 First diagnosis      
≥50§     2.51§ (1.42-3.61)/ 20
≥50#     1.62# (0.67-2.5) 11
50-59      
60-69     0/0 0§/0#
≥70     1.16§ (0–0.76)/0# 2§/0#
3.61§ (1.97-6.25)/ 18§/11#
2.48# (1.03-3.93)  
All ages      22§/11#
     1.89§ (1.1-1.27)/  
     1.22# (1.9-5.0)  
Any diagnosis:      
≥50      117§/70#
50-59      4§/1#
60-69      16§/3#
≥70      97§/66#
Brisson 2003 [22] England & Wales 1991-2000 45-64$   0.014 0.002 0.612 2$
≥65$   0.566 0.061 3.190 47
all ages$$   0.094 0.031 2.722) 49
Edmunds 2001 [2] England & Wales 1995-1999 ≥60   2.0 – 4.0    
50-54    0.009   
55-59    0.009   
60-64    0.027   
65-69    0.027   
70-74    0.035   
75-79    0.092   
80-84    0.487   
≥85    2.018   
  1. *in those with diabetes, COPD and cardiovascular; § all; #immuno-competent; $data from national statistics; $$ HES data base.