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Table 1 Characteristics of included studies

From: Herpes zoster-associated mortality in Europe: a systematic review

Study ID [ref] Country/Dates Data source HZ diagnosis Age (years) Comorbidity HZ-associated mortality data available or calculated*
Bilcke 2012 [21] Belgium/1990-2007 National death certificates Code for HZ as possible cause of death (no indication of primary or associated) and independent evaluation by 5 experts ≥60 None Overall incidence
Gonzalez Chiappe 2010 [27] France/2000-2007 National death certificate database (INSERM CepiDC: http://www.cepidc.inserm.fr/) ICD-10 codes B020.0-B020.9 as primary or associated cause of death 96.8% of deaths occurred in ≥65 21.6% had ≥1 underlying condition (59.6% malignancies, 12.5% diabetes, 10.9% blood dyscrasias and some immune deficiencies) Age-specific incidence; disease-specific number of HZ deaths and hospital fatality rate*
Ultsch 2011 [30] Germany/2007-2008 Federal Health Monitoring database ICD-10 codes of primary disease ≥50 None Overall, and age- and gender-specific incidences and hospital fatality rate*
van Lier 2010 [31] Netherlands/2000-2007 National Statistics (CBS) database ICD-10 codes B02 and G530 as primary cause of death 92% of deaths in ≥75 None Number of HZ deaths; incidence of HZ mortality*
de Melker 2006 [23] Netherlands/1996-2002 National Statistics (CBS) database ICD-10 code B02 as primary cause of death 97% in ≥60 None Number of VZV deaths, incidence of HZ mortality*
Mesquita 2013 [28] Portugal/2000-2010 National Health Hospital Ministry Database IDC-9 codes 053.10-13, 053.19-22, 053. 29, 053.71, 053.79, 053.8, 053.9 as primary diagnosis at hospital admission All ages, with 10-year groups from 50 to 99 None In-hospital fatality rate (not available by gender)
Perez-Sola 2011 [29] Spain/2000-2006 Registry for drug safety in rheumatic patients treated with anti-TNF (100 Spanish health centres) Microbiological diagnosis 50 (mean; SD = 14) Rheumatic diseases treated with TNF antagonists Number of HZ deaths
Gil 2009 [24] Spain/1998-2004 National hospital discharge database (CMBD) ICD-9 code for primary or secondary diagnosis: 0.53, 053.0-053.9 68.3 (SD = 15.5) for hospitalisations None Number of HZ deaths; age-specific hospital-mortality incidence; age-specific hospital fatality rate
Gil-Prieto 2011 [26] Spain/1998-2004 National hospital discharge database (CMBD) ICD-9 code for primary or secondary diagnosis (053; 053.0-053.9) >50 60.8% with diabetes, COPD and/or cardiovascular diseases, Exclusion of immunocompromised Overall, age-specific and disease-specific hospital fatality rate
Gil-Prieto 2012 [25] Spain/1997-2008 National hospital discharge database (CMBD) ICD-9-CM code for primary or secondary diagnosis for HZ ophthalmicus HZO 053.2, 053.20-22, 053.29 >50; 50–59; 60–69; >70 25% immunocompromised (all ages) Number of HZO deaths; HZO overall hospital-fatality rate; HZO age specific hospital-fatality rate
Comorbidities (cardiac chronic diseases, diabetes, COPD, asthma, chronic renal diseases)
Brisson 2003 [22] England and Wales/1993-2000 Hospitalisation Episode Statistics database (national) & Office for National Statistics (death certificates) ICD-10 code B02 as primary diagnosis and ICD Code for HZ as cause of death 45-64; 65+ 8% with underlying conditions Number of HZ deaths; Age-specific incidence; hospital-fatality rate
Edmunds 2001 [2] England and Wales/1998 (1985–94; 1995–1999) Hospitalisation Episode Statistics database (national) & Office for National Statistics (death certificates) ICD-10 code B02 in any of the 7 diagnosis fields/ICD-9 code 053 death (no details for primary or associated) 45+; and 5-year sub-groups None Age-specific mortality and case fatality rate
  1. *to indicate that these have been calculated.