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Table 3 Estimates of the number needed to screen and treat (NNS) for TB infection to prevent one case of active TB in the subsequent 5 years among groups by demographic and diabetes status in California

From: Increased risk of tuberculosis among foreign-born persons with diabetes in California, 2010–2012

Target population of TB screening and treatment NNS base case TB Infection prevalencea Rate of progression to active TBa
High Low High Low
All adults 7,930 6,667 10,000 3,846 14,286
All foreign-born adults 1,526 1,136 2,128 763 2,941
All adults with diabetes 2,740 2,222 3,448 1,370 5,556
 U.S.-born adults with diabetes 9,551 7,143 12,500 4,762 20,000
 Foreign-born adults with diabetes 596 442 826 298 1,163
Foreign-born adults with diabetes by location of birth      
 Latin America 741 526 877 370 1,493
 Southeast Asia/Pacific Islands 296 206 361 148 585
 East Asia 372 260 452 186 730
 South Asia 335 234 408 168 662
 Europe 2,221 1,493 3,448 1,111 4,545
 Africa/Middle East 384 270 562 192 769
  1. aHigh and low indicate the range of NNS using a range of TB infection prevalence and Rate of progression to active disease. See Additional file 1: Table S1 for inputs and ranges used.