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Table 3 Estimates of the number needed to screen and treat (NNS) for TB infection to prevent one case of active TB in the subsequent 5 years among groups by demographic and diabetes status in California

From: Increased risk of tuberculosis among foreign-born persons with diabetes in California, 2010–2012

Target population of TB screening and treatment

NNS base case

TB Infection prevalencea

Rate of progression to active TBa

High

Low

High

Low

All adults

7,930

6,667

10,000

3,846

14,286

All foreign-born adults

1,526

1,136

2,128

763

2,941

All adults with diabetes

2,740

2,222

3,448

1,370

5,556

 U.S.-born adults with diabetes

9,551

7,143

12,500

4,762

20,000

 Foreign-born adults with diabetes

596

442

826

298

1,163

Foreign-born adults with diabetes by location of birth

     

 Latin America

741

526

877

370

1,493

 Southeast Asia/Pacific Islands

296

206

361

148

585

 East Asia

372

260

452

186

730

 South Asia

335

234

408

168

662

 Europe

2,221

1,493

3,448

1,111

4,545

 Africa/Middle East

384

270

562

192

769

  1. aHigh and low indicate the range of NNS using a range of TB infection prevalence and Rate of progression to active disease. See Additional file 1: Table S1 for inputs and ranges used.