Skip to main content

Table 4 Univariate and multivariate Poisson regression with death for all-causes as the outcome

From: Cancer incidence and mortality for all causes in HIV-infected patients over a quarter century: a multicentre cohort study

  

Univariate model

Multivariate model

Variables

Categories

RR

95% CI

RR*

95% CI

Gender

Male vs Female

1.55

(1.42-1.70)

1.24

(1.12-1.36)

Age at enrolment (years)

18-34

Ref.

 

Ref.

 
 

35-44

0.96

(0.88-1.06)

1.53

(1.36-1.71)

 

45-54

1.28

(1.12-1.47)

2.41

(2.05-2.83)

 

55-64

1.56

(1.27-1.92)

2.66

(2.13-3.33)

 

≥65

3.06

(2.24-4.19)

5.41

(3.89-7.52)

Year of enrolment

1986-1989

2.41

(1.99-2.91)

1.55

(1.25-1.94)

 

1990-1993

2.23

(1.84-2.70)

1.43

(1.15-1.78)

 

1994-1997

1.63

(1.34-1.98)

0.89

(0.71-1.10)

 

1998-2001

1.23

(1.00-1.51)

1.11

(0.90-1.36)

 

2002-2005

1.01

(0.81-1.27)

1.00

(0.80-1.26)

 

2006-2012

Ref.

 

Ref.

 

IDUs

Yes vs No

1.76

(1.62-1.90)

1.54

(1.40-1.70)

AIDS-event

Yes vs No

17.55

(16.22-18.99)

3.75

(3.43-4.11)

HBV/HCV co-infection

Yes vs No

0.95

(0.89-1.03)

  

CD4 cell count, cell/mm3

0-49

44.92

(37.90-53.25)

4.10

(3.62-4.65)

 

50-99

17.58

(14.48-21.33)

2.73

(2.36-3.16)

 

100-199

7.78

(6.45-9.39)

1.83

(1.62-2.08)

 

200-349

3.02

(2.45-3.67)

1.47

(1.31-1.65)

 

350-499

1.64

(1.32-2.04)

1.15

(1.01-1.30)

 

≥500

Ref.

 

Ref.

 

Antiretroviral therapy

cART

Ref.

 

Ref.

 
 

Subobtimal cART

3.26

(2.91-3.65)

2.18

(1.95-2.44)

 

No therapy

2.14

(1.96-2.33)

8.19

(7.23-9.27)

Cancer occurrence

Without cancer

Ref.

 

Ref.

 
 

ADC

14.60

(12.51-17.03)

1.22

(1.08-1.38)

 

NADC

10.48

(8.49-12.93)

1.29

(1.12-1.50)

  1. Time-dependent Poisson regression models, with observational period divided into intervals of 1-year duration. Gender, age at enrolment, year of enrolment, intravenous drug use as risk factors and hepatitis C or B virus co-infection were included in the model as fixed covariates. CD4 cell count, AIDS events (ADC was not considered as an AIDS event), antiretroviral therapy and cancer occurrence were included as time-dependent covariates, considering at enrolment and every year.
  2. *Adjusted for all the variables in the model.
  3. Abbreviations: RR relative risk, 95% CI 95% confidence interval, IDUs intravenous drug users, HBV/HCV co-infection hepatitis B virus/hepatitis C virus positivity, cART combined antiretroviral therapy.