From: Modeling the impact of tuberculosis interventions on epidemiologic outcomes and health system costs
General intervention | Specific parameter changed1 | Projected changes in outcomes related to the primary active cases and Ranking of impact3 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 | Parameter | Pre-intervention | Post-intervention | Death during diagnosis and treatment phase | Cure due to treatment | Secondary cases generated from primary cases | Health system costs | ||||
Change in outcome | Rank of impact | Change in outcome | Rank of impact | Change in outcome | Rank of impact | Change in outcome | Rank of impact | ||||
Baseline outcomes | - | - | - | 10 · 05 |  | 0 · 62 |  | 22 · 99 |  | $5,238 · 87 |  |
Community Education | Patient delay2 | 11% | 6% | −0 · 14 | 3 | 0 · 01 | 5 | −0 · 26 | 5 | 111 · 34 | 3 |
DOTS expansion for diagnosis | Incorrect Diagnostic Test | 60% | 35% | −1 · 88 | 1 | 0 · 40 | 2 | −2 · 47 | 1 | 2947 · 81 | 9 |
Diagnostic Delay2 | 8% | 0 · 5% | −0 · 11 | 4 | 0 · 02 | 4 | −0 · 27 | 4 | 132 · 69 | 4 | |
Loss to follow up during Diagnosis | 25% | 14% | −0 · 45 | 2 | 0 · 10 | 3 | −0 · 60 | 3 | 710 · 63 | 8 | |
DOTS Expansion for Treatment | Incorrect Treatment | 79% | 13% | 0 · 00 | 6 | 1 · 98 | 1 | −1 · 54 | 2 | 363 · 20 | 7 |
Non specific DOTS Expansion (NTP Strengthening) | Access Government Facility | 94 · 5% | 97 · 5% | −0 · 09 | 5 | 0 · 02 | 4 | −0 · 12 | 6 | 164 · 65 | 5 |
HIV/ ART therapy programmes | HIV/TB Death rate | 12% | 10% | 0 · 00 | 6 | 0 · 00 | 6 | 0 · 00 | 8 | 0 · 00 | 2 |
HIV/TB Relapse rate | 16% | 1% | 0 · 00 | 6 | 0 · 00 | 6 | 0 · 00 | 8 | 0 · 00 | 2 | |
HIV/TB Reactivation rate | 3 · 4% | 2% | 0 · 00 | 7 | 0 · 01 | 5 | 0 · 05 | 9 | −142 · 43 | 1 | |
MDR-TB related interventions | DST performed | 20% | 50% | 0 · 00 | 6 | 0 · 02 | 4 | −0 · 03 | 7 | 232 · 19 | 6 |
Loss to follow up during MDR Treatment | 22% | 11% | 0 · 00 | 6 | 0 · 00 | 6 | 0 · 00 | 8 | 10 · 11 | 3 |