Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5–9 years in Greenland, Ukraine and Poland

Table 5 Mean differences (points) ^a for DCDQ-score in relation to pregnancy tertiles of CB-153 and p,p′-DDE

		Greenland, n = 520			Ukraine, n = 492			Poland, n = 91			All, n = 1,103
		Diff. (95% CI)	Diff. (95% CI)	β^b(95% CI)	Diff. (95% CI)	Diff. (95% CI)	β^b(95% CI)	Diff. (95% CI)	Diff. (95% CI)	β^b(95% CI)	Diff. (95% CI)	Diff. (95% CI)	β^b(95% CI)
Exposure	Outcome	Medium	High	Cont.	Medium	High	Cont.	Medium	High	Cont.	Medium	High	Cont.
CB-153	DCDQ	0.1 (−1.8, 2.0)	−0.6 (−2.6, 1.4)	0.2 (−0.6, 1.0)	−1.2 (−2.8, 0.4)	−0.5 (−2.2, 1.2)	−0.3 (−1.3, 0.7)	−2.7 (−8.2, 2.8)	−0.9 (−6.7, 5.0)	−0.6 (−3.9, 2.6)	0.2 (−1.1, 1.5)	0.5 (−2.2, 1.3)	−0.1 (−0.7, 0.5)
p,p′-DDE	DCDQ	−0.4 (−2.3, 1.5)	0.3 (−1.7, 2.2)	−0.1 (−0.8, 0.7)	1.1 (−0.5, 2.7)	0.6 (−1.0, 2.3)	0.6 (−0.6, 1.8)	−2.5 (−7.9, 2.9)	−2.0 (−7.8, 3.8)	−1.5 (−5.4, 2.4)	−0.5 (−1.8, 0.8)	−0.5 (−1.9, 0.9)	−0.1 (−0.7, 0.5)

Abbreviations: CB-153 2,2′,4,4′,5,5′-hexachlorobiphenyl, CI confidence interval, Cont. Continuous, DCDQ developmental coordination disorder questionnaire, Diff adjusted mean difference (points), p,p′-DDE 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene, Ref. reference group. ^aAdjusted for: maternal pre-pregnancy smoking, maternal pre-pregnancy alcohol-intake, maternal education, parity, maternal age at birth, breast-feeding, preterm birth, gestational age at blood-sampling, child sex and child age at interview. Low exposure is the reference group. ^bLog-transformed continuous exposure in linear regression analyses. Imputation-based analyses.

ISSN: 1471-2458