Table 2 Frequencies of alleles and genotypes in rs16969968-, rs578776-, and rs12914008-tagging loci in the studied sample and in the HapMap CEU* reference population
From: Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey
Polymorphism | Allele/ genotype | Frequency (%) | pvalue | |
|---|---|---|---|---|
Kashubians(North Poland) | HapMap CEU/Global MAF** | |||
rs16969968 (CHRNA5) | A | 30.6 | 38.5 | 0.02 |
| Â | G | 69.4 | 61.5 | |
| Â | AA | 9.7 | 15.9 | 0.04 |
| Â | AG | 41.8 | 45.1 | 0.50 |
| Â | GG | 48.5 | 38.9 | 0.05 |
rs578776 (CHRNA3) | C | 72.1 | 75.2 | 0.33 |
| Â | T | 27.9 | 24.8 | |
| Â | CC | 51.7 | 56.6 | 0.32 |
| Â | CT | 40.9 | 37.2 | 0.45 |
| Â | TT | 7.4 | 6.2 | 0.63 |
rs12914008 (CHRNB4) | A | 4.6 | 3.3/1.7 | 0.68 |
| Â | G | 95.4 | 96.7 | |
| Â | AA | 0.3 | 0 | 0.42 |
| Â | AG | 8.6 | 6.7 | 0.78 |
| Â | GG | 91.1 | 93.3 | 0.72 |