Table 2 Subgroup analysis of ovarian cancer for alcohol intake versus nondrinker
Category | Subgroup | Number of cohorts | RR and 95% CI | P value | P value for heterogeneity test |
|---|---|---|---|---|---|
Drinker versus nondrinker | Country | ||||
US | 9 | 1.05 (0.94-1.17) | 0.428 | 0.126 | |
Other | 5 | 0.96 (0.92-0.99) | 0.017 | 0.597 | |
Type of alcohol intake | |||||
Wine | 2 | 1.13 (0.92-1.38) | 0.254 | 0.085 | |
Beer | 2 | 1.01 (0.86-1.18) | 0.914 | 0.250 | |
Liquor | 2 | 1.02 (0.92-1.14) | 0.652 | 0.789 | |
Follow-up duration | |||||
More than 10 years | 7 | 1.08 (0.98-1.19) | 0.136 | 0.348 | |
Less than 10 years | 7 | 0.98 (0.91-1.06) | 0.631 | 0.282 | |
Adjusted oral contraceptive | |||||
Yes | 9 | 1.05 (0.96-1.16) | 0.262 | 0.038 | |
No | 5 | 0.98 (0.87-1.12) | 0.797 | 0.506 | |
Adjusted hormone replacement therapy | |||||
Yes | 10 | 0.98 (0.94-1.03) | 0.521 | 0.373 | |
No | 4 | 1.05 (0.81-1.37) | 0.700 | 0.064 | |
Adjusted menopausal status | |||||
Yes | 8 | 1.08 (0.98-1.19) | 0.140 | 0.219 | |
No | 6 | 0.95 (0.92-0.99) | 0.009 | 0.674 | |
Adjusted smoking status | |||||
Yes | 9 | 0.96 (0.92-0.99) | 0.011 | 0.716 | |
No | 5 | 1.14 (1.01-1.30) | 0.036 | 0.285 | |
Adjusted body mass index | |||||
Yes | 6 | 0.96 (0.92-0.99) | 0.010 | 0.890 | |
No | 8 | 1.07 (0.96-1.21) | 0.226 | 0.139 | |
NOS score | |||||
8 or 9 | 8 | 1.04 (0.95-1.14) | 0.388 | 0.057 | |
<8 | 6 | 1.01 (0.89-1.15) | 0.859 | 0.368 | |
Low alcohol intake versus nondrinker | Country | ||||
US | 9 | 1.01 (0.92-1.12) | 0.803 | 0.665 | |
Other | 4 | 0.96 (0.92-1.00) | 0.033 | 0.686 | |
Follow-up duration | |||||
More than 10 years | 6 | 1.06 (0.95-1.18) | 0.315 | 0.595 | |
Less than 10 years | 7 | 0.95 (0.91-0.99) | 0.017 | 0.957 | |
Adjusted oral contraceptive | |||||
Yes | 9 | 0.97 (0.93-1.00) | 0.083 | 0.520 | |
No | 4 | 0.94 (0.80-1.09) | 0.396 | 0.784 | |
Adjusted hormone replacement therapy | |||||
Yes | 9 | 0.96 (0.92-1.00) | 0.039 | 0.871 | |
No | 4 | 1.06 (0.87-1.28) | 0.584 | 0.335 | |
Adjusted menopausal status | |||||
Yes | 7 | 1.03 (0.93-1.13) | 0.595 | 0.753 | |
No | 6 | 0.95 (0.92-0.99) | 0.024 | 0.680 | |
Adjusted smoking status | |||||
Yes | 8 | 0.96 (0.92-0.99) | 0.024 | 0.817 | |
No | 5 | 1.07 (0.94-1.22) | 0.331 | 0.691 | |
Adjusted body mass index | |||||
Yes | 5 | 0.96 (0.92-0.99) | 0.025 | 0.871 | |
No | 8 | 1.03 (0.93-1.15) | 0.534 | 0.624 | |
NOS score | |||||
8 or 9 | 8 | 0.98 (0.93-1.03) | 0.408 | 0.391 | |
<8 | 5 | 0.95 (0.82-1.10) | 0.526 | 0.911 | |
Moderate alcohol intake versus nondrinker | Country | ||||
US | 9 | 1.20 (0.95-1.52) | 0.126 | 0.296 | |
Other | 4 | 0.97 (0.90-1.05) | 0.440 | 0.858 | |
Follow-up duration | |||||
More than 10 years | 6 | 1.24 (0.97-1.60) | 0.087 | 0.496 | |
Less than 10 years | 7 | 1.02 (0.83-1.25) | 0.876 | 0.213 | |
Adjusted oral contraceptive | |||||
Yes | 9 | 1.06 (0.89-1.26) | 0.537 | 0.239 | |
No | 4 | 1.15 (0.77-1.73) | 0.500 | 0.281 | |
Adjusted hormone replacement therapy | |||||
Yes | 9 | 1.09 (0.92-1.30) | 0.307 | 0.185 | |
No | 4 | 0.95 (0.51-1.74) | 0.859 | 0.207 | |
Adjusted menopausal status | |||||
Yes | 7 | 1.31 (1.08-1.59) | 0.007 | 0.538 | |
No | 6 | 0.96 (0.89-1.04) | 0.323 | 0.785 | |
Adjusted smoking status | |||||
Yes | 8 | 0.98 (0.89-1.08) | 0.662 | 0.412 | |
No | 5 | 1.37 (1.07-1.75) | 0.012 | 0.734 | |
Adjusted body mass index | |||||
Yes | 5 | 0.97 (0.90-1.04) | 0.370 | 0.938 | |
No | 8 | 1.26 (1.01-1.58) | 0.037 | 0.344 | |
NOS score | |||||
8 or 9 | 8 | 1.05 (0.89-1.23) | 0.580 | 0.300 | |
<8 | 5 | 1.08 (0.73-1.59) | 0.713 | 0.249 | |
Heavy alcohol intake versus nondrinker | Country | ||||
US | 9 | 1.04 (0.80-1.35) | 0.758 | 0.605 | |
Other | 3 | 1.11 (0.79-1.56) | 0.539 | 0.178 | |
Follow-up duration | |||||
More than 10 years | 5 | 1.07 (0.76-1.51) | 0.691 | 0.339 | |
Less than 10 years | 7 | 0.98 (0.86-1.12) | 0.757 | 0.517 | |
Adjusted oral contraceptive | |||||
Yes | 8 | 1.05 (0.87-1.27) | 0.591 | 0.330 | |
No | 4 | 0.94 (0.62-1.44) | 0.783 | 0.591 | |
Adjusted hormone replacement therapy | |||||
Yes | 8 | 0.96 (0.85-1.09) | 0.536 | 0.814 | |
No | 4 | 1.76 (1.03-3.01) | 0.038 | 0.655 | |
Adjusted menopausal status | |||||
Yes | 6 | 1.08 (0.83-1.40) | 0.560 | 0.446 | |
No | 6 | 0.97 (0.84-1.11) | 0.648 | 0.452 | |
Adjusted smoking status | |||||
Yes | 8 | 0.95 (0.83-1.08) | 0.436 | 0.651 | |
No | 4 | 1.32 (0.94-1.84) | 0.104 | 0.637 | |
Adjusted body mass index | |||||
Yes | 4 | 1.05 (0.77-1.43) | 0.760 | 0.244 | |
No | 8 | 1.09 (0.84-1.41) | 0.522 | 0.634 | |
NOS score | |||||
8 or 9 | 7 | 1.04 (0.83-1.30) | 0.721 | 0.277 | |
<8 | 5 | 1.08 (0.76-1.54) | 0.654 | 0.694 | |