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Table 3 Relationship between sustained change* in secondary outcomes and progression to T2D by trial group.

From: Prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention RCT in Newcastle upon Tyne, UK

  Number in intervention group (%) Number in control group (%) Total number (%) Number of cases of T2D over five years follow-up
Body weight     
Sustained beneficial change 23 (45) 24 (47) 47 (46) 3
No sustained beneficial change 28 (55) 27 (53) 55 (54) 13
Physical activity score     
Sustained beneficial change 18 (35) 19 (37) 37 (36) 2
No sustained beneficial change 33 (65) 32 (63) 65 (64) 14
Intake of dietary fibre     
Sustained beneficial change 15 (29) 15 (29) 30 (29) 3
No sustained beneficial change 36 (71) 36 (71) 72 (71) 13
% energy intake from fat     
Sustained beneficial change 21 (41) 21 (41) 42 (41) 3
No sustained beneficial change 30 (59) 30 (59) 60 (59) 13
% energy intake from carbohydrate     
Sustained beneficial change 15 (29) 16 (31) 31 (30) 2
No sustained beneficial change 36 (71) 35 (69) 71 (70) 14
  1. * Sustained beneficial change in secondary outcome measures was defined as: a beneficial change (>0.01 units) maintained for two or more years (i.e. weight loss, reduction in % energy intake from fat, increase in % intake from carbohydrate, increase in intake of dietary fibre and increase in physical activity score).