|
First-phase analysis
|
Second-phase analysis
|
Two-phase analysis
|
---|
| | |
Partly adjusteda
| | | |
Partly adjustedb
| |
Fully adjustedc
| | | |
---|
NOX
μg/m3
|
Cases
N(%)
|
Controls
N(%)
|
ORd
|
CI
|
Cases
N(%)
|
Controls
N(%)
|
ORe
|
CI
|
ORf
|
CI
|
ORg
|
CIh
|
---|
0–<10
|
1667 (34)
|
197371 (35)
|
1
| |
1492 (34)
|
1784 (38)
|
1
| |
1
| |
1
| |
10–<20
|
1944 (40)
|
221981 (40)
|
1.03
|
0.97–1.10
|
1699 (39)
|
1923 (41)
|
1.07
|
0.91–1.25
|
1.00
|
0.85–1.2
|
0.97
|
0.90–1.05
|
20–<30
|
1065 (22)
|
110001 (20)
|
1.05
|
0.97–1.14
|
981 (22)
|
867 (18)
|
1.10
|
0.87–1.39
|
1.00
|
0.79–1.3
|
0.95
|
0.86–1.06
|
30–<60i
|
228 (5)
|
27559 (5)
|
0.91
|
0.79–1.05
|
203 (5)
|
142 (3)
|
1.28
|
0.90–1.82
|
1.20
|
0.85–1.76
|
0.87
|
0.73–1.03
|
-
Partly adjusted first- and second-phase estimates, fully adjusted second-phase estimates and two-phase estimates: The two-phase estimates were calculated according to formula 1.
-
a Adjusted for birth year category, sex, birth country and marital status.
-
b Adjusted for a and for geographical area.
-
c Adjusted for a, b and for smoking, diabetes and medication for hypertension.
-
d The partly adjusted first-phase OR for an increase of 10 μg/m3 in NOx was OR1;Partl_adj= 0.99 (0.95–1.02), p for trend = 0.44.
-
e The partly adjusted second-phase OR for an increase of 10 μg/m3 in NOx was OR2;Partly_adj= 1.09 (0.95–1.26), p for trend p = 0.21.
-
f The fully adjusted second-phase OR for an increase of 10 μg/m3 in NOx was OR2;Fully_adjj= 1.07 (0.93–1.24), p = 0.33
-
g The two-phase OR for an increase of 10 μg/m3 in NOx was OR1+2 = 0.97.
-
h The widths of the two-phase CIs are likely slightly overestimated, due to dependence between the three combined estimates that we did not take into account.
-
iMedian level of NOx in the category 30–<60 μg/m3 is 33.0 μg/m3 (10th–90th percentile: 30.4–40.5)