| First-phase analysis | Second-phase analysis | Two-phase analysis |
---|
| | | Partly adjusteda
| | | | Partly adjustedb
| | Fully adjustedc
| | | |
---|
NOX
μg/m3
| Cases N(%) | Controls N(%) | ORd
| CI | Cases N(%) | Controls N(%) | ORe
| CI | ORf
| CI | ORg
| CIh
|
---|
0–<10 | 1667 (34) | 197371 (35) | 1 | | 1492 (34) | 1784 (38) | 1 | | 1 | | 1 | |
10–<20 | 1944 (40) | 221981 (40) | 1.03 | 0.97–1.10 | 1699 (39) | 1923 (41) | 1.07 | 0.91–1.25 | 1.00 | 0.85–1.2 | 0.97 | 0.90–1.05 |
20–<30 | 1065 (22) | 110001 (20) | 1.05 | 0.97–1.14 | 981 (22) | 867 (18) | 1.10 | 0.87–1.39 | 1.00 | 0.79–1.3 | 0.95 | 0.86–1.06 |
30–<60i
| 228 (5) | 27559 (5) | 0.91 | 0.79–1.05 | 203 (5) | 142 (3) | 1.28 | 0.90–1.82 | 1.20 | 0.85–1.76 | 0.87 | 0.73–1.03 |
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Partly adjusted first- and second-phase estimates, fully adjusted second-phase estimates and two-phase estimates: The two-phase estimates were calculated according to formula 1.
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a Adjusted for birth year category, sex, birth country and marital status.
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b Adjusted for a and for geographical area.
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c Adjusted for a, b and for smoking, diabetes and medication for hypertension.
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d The partly adjusted first-phase OR for an increase of 10 μg/m3 in NOx was OR1;Partl_adj= 0.99 (0.95–1.02), p for trend = 0.44.
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e The partly adjusted second-phase OR for an increase of 10 μg/m3 in NOx was OR2;Partly_adj= 1.09 (0.95–1.26), p for trend p = 0.21.
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f The fully adjusted second-phase OR for an increase of 10 μg/m3 in NOx was OR2;Fully_adjj= 1.07 (0.93–1.24), p = 0.33
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g The two-phase OR for an increase of 10 μg/m3 in NOx was OR1+2 = 0.97.
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h The widths of the two-phase CIs are likely slightly overestimated, due to dependence between the three combined estimates that we did not take into account.
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iMedian level of NOx in the category 30–<60 μg/m3 is 33.0 μg/m3 (10th–90th percentile: 30.4–40.5)