Tertiles of hopelessness score in relation to physical fitness and at least moderate LTPA. LTPA categories were adjusted for age, presence of CVD, adult socioeconomic status, smoking and alcohol consumption. Unfit and physically inactive men had the highest risk for hopelessness. Those men who exercised most and were fit had the lowest risk (versus the unfit and least active category, OR 0.49, 95% CI 0.33–0.73, P for the trend < 0.001). The interaction term for VO2max and LTPA with respect to hopelessness was not significant (P = 0.348).