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Table 3 Cox multivariate regression for all cause, cardiovascular, ischaemic heart disease, cerebro disease and non-cardiovascular mortality. Effect of HbA1c level and diabetes status were modelled separately (models 1 and 2) and together (model 3)

From: An investigation of the population impact of variation in HbA1clevels in older people in England and Wales: From a population based multi-centre longitudinal study

Cause of death   Relative risk adjusted for age & sex (95% CI) P value Relative risk adjusted for age, sex and other risk factors* (95% CI) P value
All causes (n = 619)
Model 1 HbA1c (per 1% increase) 1.1 (1.0,1.3) 0.03 1.1 (1.0, 1.2) 0.03
Model 2 Diabetes history (yes v no) 1.2 (0.8, 1.8) 0.38 1.2 (0.8, 1.9) 0.44
Model 3 HbA1c (per 1% increase) 1.2 (1.0, 1.3) 0.04 1.2 (1.0, 1.4) 0.08
  Diabetes history (yes v no) 0.9 (0.6, 1.4) 0.67 0.8 (0.4, 1.6) 0.61
Cardiovascular disease (n = 316)
Model 1 HbA1c (per 1% increase) 1.2 (1.1, 1.4) 0.001 1.2 (1.1 1.4) 0.002
Model 2 Diabetes history (yes v no) 1.6 (1.0, 2.6) 0.056 1.5 (0.1, 2.6) 0.10
Model 3 HbA1c (per 1% increase) 1.2 (1.1, 1.4) 0.01 1.2 (1.1, 1.5) 0.01
  Diabetes history (yes v no) 1.1 (0.6, 1.8) 0.79 0.9 (0.5, 1.8) 0.81
Ischaemic heart disease (n = 165)
Model 1 HbA1c (per 1% increase) 1.2 (1.1, 1.5) 0.01 1.2 (1.0, 1.4) 0.01
Model 2 Diabetes history (yes v no) 1.7 (1.0, 3.1) 0.08 1.5 (0.8, 3.0) 0.24
Model 3 HbA1c (per 1% increase) 1.2 (1.0, 1.5) 0.06 1.3 (1.0, 1.6) 0.03
  Diabetes history (yes v no) 1.2 (0.6, 2.1) 0.63 0.8 (0.4, 1.9) 0.68
Cerebro disease (n = 120)
Model 1 HbA1c (per 1% increase) 1.2 (1.0, 1.5) 0.08 1.1 (0.9, 1.5) 0.29
Model 2 Diabetes history (yes v no) 1.6 (0.8, 3.3) 0.17 1.4 (0.7, 2.7) 0.40
Model 3 HbA1c (per 1% increase) 1.2 (0.9, 1.5) 0.29 1.1 (0.8, 1.6) 0.42
  Diabetes history (yes v no) 1.2 (0.6, 2.8) 0.61 1.0 (0.4, 2.4) 0.97
Non-cardiovascular disease (n = 303)
Model 1 HbA1c (per 1% increase) 1.0 (0.9, 1.2) 0.87 1.0 (0.8, 1.2) 0.97
Model 2 Diabetes history (yes v no) 0.8 (0.5, 1.6) 0.58 0.8 (0.4, 1.7) 0.65
Model 3 HbA1c (per 1% increase) 1.1 (0.9, 1.4) 0.57 1.1 (0.8, 1.4) 0.68
  Diabetes history (yes v no) 0.8 (0.4, 1.6) 0.46 0.7 (0.2, 2.2) 0.58
  1. * Risk factors are history of heart attack, stroke, high blood pressure and smoke status