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Table 3 Results of the feasibility study: process indicators and critical points

From: Can colorectal cancer mass-screening organization be evidence-based? Lessons from failures: The experimental and pilot phases of the Lazio program

Indicators

values

range among

centres

critical points

Program activation

   target population

300000

  

   N of centres started

50% (10/20)

 

See discussion

   population of active centres

65922 (22,0%)

  

the following data refer only to the active centres

GPs participation

   % of GP that agreed to participate

10,8% (57/526) 60,0% (57/95)$

(0,0 – 90,0)

GPs were actually involved in only 6 centres: in some LHUs,

administrative barriers prevented the participation; no interest by the GPs;

some GPs initially agreed but never send the list of target population.

Program extension (invited population/target)

   Total

41,1% (65922)

 

Most of the GPs do not actively invite, but only distribute the tests

opportunistically: difficult to exactly determine the contacted

population.

   GP

21,0% (20315)

(42,2–8,0)

 

   Hospital

50,1% (45607)

(100,0–14,4)

Too slow invitation rhythm: the program did not cover the

whole target population within the two-year period.

Compliance to FOBT (proportion of returned test/invited population)

   all

26,5% (27124)

  

   GP

79,9% (4258)

(73,1 – 91,8)

Impossible to monitor what the GP does. The compliance is biased

because of opportunistic strategies, without active invitation

by the GP.

   Hospital

16,6% (22866)

(4,7 – 34,1)

Low compliance: no accessibility

Positivity rate

 

7,1% (6908)

(3,2 – 9,2)

For 288 (%) tests the results were not available: high level of

lost samples and lost responses.

Compliance to colonoscopy°

 

49,1% (288)

(0,0 – 76,7)

Impossible to determine if missing data or low compliance.

Detection rate*

   Total

17,1/1000 (N 71)

 

Very few centres input data correctly and timely.

cancer

3,6/1000 (N 15)

  

high grade adenomas

13,5/1000 (N 56)

  

   Low grade adenomas

N 17

  

Waiting time for colonoscopy§

   within 30 days from FOBT

55,1%

 

Few colonoscopies due, but centres too busy. Very few centres input data correctly and timely.

   31 and 60 days from FOBT

22,8%

  

   after 60 days from FOBT

22,1%

  
  1. ° Based on 288 positive tests with complete follow up; high grade adenomas includes: 8% tubular with high grade dysplasia; 25% tubular-villous with high grade dysplasia; 24% tubular-villous with moderate dysplasia; 24% tubular-villous with low grade dysplasia; 4% villous with high grade dysplasia; 3% villous with moderate dysplasia; 1% villous with low grade dysplasia; 4% hyperplasic polyps; 5% 3 or more adenomas with low moderate dysplasia; 3% unknown. Low grade adenomas include: 73% of low grade and 23% of moderate tubular dysplasia; 4% unknown.
  2. * Based on 4155 tests with full information.
  3. § Based on 140 colonoscopies with full information
  4. $ Considering only the 6 centres that activated the collaboration with the GPs