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Table 3 Cox regression analysis for model exploring interaction between birth weight and exposure to the occupation (C).

From: Cardiovascular disease in a cohort exposed to the 1940–45 Channel Islands occupation

  Covariate
(referent category)
Hazard
Ratio
95%
confidence
intervals
p value
Stratified by exposure to the occupation, and adjusted for potential confounders1 Exposed individuals
  Birth weight amongst those exposed to the occupation (per kg increase) 1.22 0.65 – 2.28 0.54
  Female sex (male) 0.63 0.33 – 1.17 0.14
  Preterm gestational age (term) 0.32 0.04 – 2.31 0.26
  Manual paternal occupation (non-manual) 0.93 0.49 – 1.77 0.82
  Rural parish of birth (urban) 1.93 0.99 – 3.75 0.05
  Unexposed individuals
  Birth weight amongst those unexposed to the occupation (per kg increase) 0.92 0.44 – 1.90 0.81
  Female sex (male) 0.93 0.42 – 2.04 0.85
  Preterm gestational age (term) -2 -2 -2
  Manual paternal occupation (non-manual) 2.53 1.15 – 5.58 0.02
  Rural parish of birth (urban) 1.15 0.51 – 2.58 0.73
  1. 1 Sex, gestational age at birth, paternal occupation at birth and parish of residence at birth were all considered potential confounders. It is important to note that the interpretation of the estimated hazard ratios for potential confounders is not straightforward since the main exposure variable (birth weight) lies on the pathway between these potential confounders and the outcome variable (CVD in later life).
  2. 2 There were no cohort members in this category who were preterm and who had also experienced a CVD event