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Table 6 Concurrent validation of 10/66 Dementia and DSM-IV dementia diagnoses

From: The 10/66 Dementia Research Group's fully operationalised DSM-IV dementia computerized diagnostic algorithm, compared with the 10/66 dementia algorithm and a clinician diagnosis: a population validation study

   Group 1 (n = 2587) Non-cases Group 2 (n = 134) 10/66 cases not confirmed by DSM-IV Group 3 (n = 188) DSM-IV cases Mean difference (group 2 vs group 1) Mean difference (group 2 vs group 3)
CSI'D' COGSCORE (cognitive test score) Mean (95% CI) 30.6 (30.5–30.6) 22.4 (21.3–23.7) 17.1 (15.9–18.3) -8.1 (-6.9 to -9.3) 5.4 (3.7 to 7.1)
  Median (IQR) 31.0 (29.6–32.1) 23.9 (20.7–27.2) 16.6 (12.3–23.4)   
CSI'D'RELSCORE(informant reports of cognitive and functional decline) Mean (95% CI) 1.1 (1.0–1.2) 8.3 (7.3–9.3) 15.4 (14.5–16.3) 7.2 (6.2 to 8.2) -7.1 (-5.8 to -8.5)
  Median (IQR) 0.5 (0.0–1.5) 7.5 (5.5–10.0) 14.3 (10.0–20.0)   
NPI-Q Severity (severity of behavioural and psychological symptoms) Mean (95% CI) 2.0 (1.9–2.1) 5.0 (4.1–5.9) 7.1 (6.3–7.9) 3.0 (2.2 to 3.9) -2.1 (-0.9 to -3.2)
  Median (IQR) 1 (0–3) 3 (1–8) 7 (2–11)   
NPI'Q' Distress (distress caused to the caregiver by BPSD) Mean (95% CI) 1.7 (1.6–1.9) 5.0 (3.9–6.1) 7.3 (6.3–8.4) 3.3 (2.2 to 4.3) -2.3 (-0.8 to -3.8)
  Median (IQR) 0 (0–2) 3 (0–7) 5 (1–12)   
WHODAS II Disability Mean (95% CI) 9.6 (9.1–10.2) 36.0 (30.8–41.2) 48.7 (44.0–53.3) 26.4 (21.2 to 31.6) -12.7 (-5.7 to -19.7)
  Median (IQR) 2.8 (0.0–13.9) 26.4 (8.3–63.2) 50.0 (19.4–77.8)   
Needs for care No care needed 96.6% 58.7% 29.8% Chi sq = 1043, 1 df, p < 0.001
  Needs care some of the time 1.9% 11.6% 15.2%   
  Needs care much of the time 1.4% 29.8% 55.1%