Two-way sensitivity analysis examining the impact of travel duration and annual risk of infection on potential cost savings with the post-trip tuberculin testing strategy, for US-born travelers. During longer trips and/or high annual infection risks, this approach becomes cost-saving, relative to no screening. The two-way sensitivity analysis assumes a 7.2% prevalence of isoniazid resistance, as in Mexico. Hence the threshold trip duration for cost savings among travelers facing infection risks as in the Dominican Republic and Haiti is shorter than in the base case scenario. The base case scenario used the higher prevalence of isoniazid resistance which has been documented in those countries (19.8% and 15.9%).