From: Adverse childhood experiences and prescription drug use in a cohort study of adult HMO patients
 | Age 18–44 years | Age 45–64 years | Age 65–89 years | |||
---|---|---|---|---|---|---|
ACE Score | Rate | RR* (95% CI) | Rate | RR* (95% CI) | Rate | RR* (95% CI) |
   0 | 5.03 | 1.00 (referent) | 10.18 | 1.00 (referent) | 17.27 | 1.00 (referent) |
   1 | 5.99 | 1.14 (1.00–1.29) | 11.19 | 1.09 (1.02–1.17) | 16.92 | 0.99 (0.94–1.05) |
   2 | 6.86 | 1.30 (1.13–1.50) | 11.33 | 1.12 (1.04–1.21) | 18.10 | 1.08 (1.00–1.16) |
   3 | 6.95 | 1.33 (1.13–1.56) | 12.11 | 1.17 (1.06–1.28) | 17.83 | 1.04 (0.93–1.15) |
   4 | 7.64 | 1.46 (1.23–1.73) | 12.59 | 1.24 (1.11–1.39) | 19.43 | 1.12 (0.98–1.29) |
   5 or more | 8.84 | 1.63 (1.38–1.93) | 15.48 | 1.45 (1.30–1.62) | 20.67 | 1.25 (1.05–1.48) |
Overall | 6.45 | Â | 11.32 | Â | 17.47 | Â |
p-value, trend | Â | < 0.0001 | Â | < 0.0001 | Â | 0.0025 |