Table 3 Clinical outcomes 0–12 months

Disease Score (0–10)

237

6.65 (1.81)

3.19 (2.27)

p < 0.001

4.00 (3.50 to 4.00)

87%

1.34

Symptom Score (0–10)

336

5.95 (1.75)

3.49 (2.12)

p < 0.001

2.50 (2.25 to 2.75)

84%

1.04

SF-36 scales (0–100)

-Physical Function

270

75.34 (22.74)

83.18 (19.41)

p < 0.001

10.00 (7.50 to 10.00)

63%

0.42

-Role Physical

267

42.51 (39.20)

67.79 (37.20)

p < 0.001

37.50 (37.50 to 50.00)

55%

0.63

-Role-Emotional

268

47.26 (41.87)

70.58 (38.09)

p < 0.001

33.34 (33.30 to 50.00)

49%

0.55

-Social Functioning

272

62.13 (25.75)

75.28 (24.37)

p < 0.001

18.75 (12.50 to 25.00)

58%

0.49

-Mental Health

271

54.21 (18.65)

65.05 (19.00)

p < 0.001

12.00 (8.00 to 14.00)

71%

0.57

-Bodily Pain

272

55.91 (28.41)

66.93 (27.65)

p < 0.001

16.00 (11.50 to 20.00)

55%

0.41

-Vitality

271

38.68 (17.85)

51.49 (18.68)

p < 0.001

15.00 (12.50 to 17.50)

68%

0.67

-General Health

268

50.86 (18.80)

58.39 (19.55)

p < 0.001

8.50 (6.00 to 10.00)

65%

0.44

SF-36 Health Change (1–5**)

272

3.23 (1.08)

2.15 (1.09)

p < 0.001

1.50 (1.00 to 1.50)

69%

0.68

SF-36 Physical Component

263

43.13 (10.25)

47.10 (9.78)

p < 0.001

3.90 (2.83 to 4.97)

68%

0.44

SF-36 Mental Component

263

38.31 (11.67)

45.01 (11.76)

p < 0.001

6.45 (4.94 to 7.96)

69%

0.55

KINDL subscales (0–100)

-Psychic

35

67,36 (15,27)

70,68 (15,64)

p = 0.188

3.41 (-2.27 to 9.09)

60%

0.20

-Somatic

35

70,57 (14,47)

75,60 (9,35)

p = 0.071

4.17 (0.00 to 9.72)

66%

0.37

-Social

35

69,90 (11,95)

73,16 (11,78)

p = 0.063

4.17 (0.00 to 7.29)

66%

0.28

-Function

33

64,39 (14,33)

67,94 (10,44)

p = 0.187

3.41 (-2.27 to 7.96)

61%

0.25

KINDL Summary Score (0–100)

35

67.86 (11.02)

71.48 (9.79)

p = 0.063

3.59 (-0.07 to 7.65)

63%

0.34

KITA subscales (0–100)

-Psychosoma

51

69.53 (15.45)

77.21 (13.60)

p = 0.001

9.38 (4.17 to 12.50)

69%

0.51

-Daily Life

56

59.23 (21.78)

68.14 (18.52)

p = 0.001

10.42 (4.17 to 14.58)

63%

0.53