Folic acid fortification and public health: Report on threshold doses above which unmetabolised folic acid appear in serum

Table 4 Serum folate and folic acid (μg/L). Samples collected on day 7 of regime A bread (50 μg in each slice) pre and post prandially.

	pre 50 μg	1 hour post	2 hrs post	3 hrs post	4 hrs post	1 hour post 2^nd slice	2 hrs post	3 hrs post
Serum folate	i	ii	iii	iv	v	vi	vii	viii
Mean	16.91	16.30	16.99	16.88	17.40	15.56	15.40	14.82
SD	6.55	6.62	6.42	6.24	7.12	5.77	6.04	5.21
CI (95%)	13.75 – 20.06	13.11 – 19.49	13.89 – 20.08	13.87 – 19.88	13.97 – 20.83	12.78 – 18.34	12.49 – 18.31	12.31 – 17.33

This table illustrates mean total serum folate (μg/L) concentrations in a group of healthy adult subject (n = 19) exposed to a folic fortified bread for 1-week. Subject were pre-saturated with folic acid supplements for 14-weeks prior to the bread. The bread was fortified with 50 μg folic acid per slice, which was administered twice a day for seven days. The samples shown here were collected on the 7^th day of bread consumption pre-prandially and post-prandially. Standard deviations and confidence intervals are also shown. Serum folic acid was not detectable at any sampling points

ISSN: 1471-2458