Folic acid fortification and public health: Report on threshold doses above which unmetabolised folic acid appear in serum

Table 3 Serum folate and serum folic acid (μg/l). Samples collected on day 7 of regime B bread (100 μg in each slice) pre and post prandially.

	pre 1^st slice	1 hour post	2 hrs post	3 hrs post	4 hrs post	1 hour post 2^nd slice	2 hrs post	3 hrs post
Serum folate	i	ii	iii	iv	v	vi	vii	viii
Mean	14.1111	14.70	15.16	14.72	14.41	14.43	13.84	13.28
SD	5.24	5.59	4.99	5.32	5.83	5.78	5.25	5.47
CI (95%)	11.59 – 16.63	12.00 – 17.39	12.75 – 17.56	12.16 – 17.28	11.60 – 17.22	11.65 – 17.22	11.23 – 16.45	10.46 – 16.10

This table illustrates mean total serum folate (μg/L) concentrations in a group of healthy adult subject (n = 19) exposed to a folic fortified bread for 1-week. Subject were pre-saturated with folic acid supplements for 14-weeks prior to the bread. The bread was fortified with 100 μg folic acid per slice, which was administered twice a day for seven days. The samples shown here were collected on the 7^th day of bread consumption pre-prandially and post-prandially. Standard deviations and confidence intervals are also shown. Serum folic acid was not detectable at any sampling points

ISSN: 1471-2458