Application of adenosine 5'-triphosphate (ATP) infusions in palliative home care: design of a randomized clinical trial

Table 1 Time schedule of outcome assessment

Outcome measure	Measurement scale or specification	Timing (in weeks)
Primary outcomes		0	2	4	6	8
Quality of Life	EORTC QLQ-C30*	X		X		X
Quality of Life	RSCL, overall question **	X	X	X	X	X
Fatigue	SFQ***	X	X	X	X	X
Physical restriction	GARS-4****	X	X	X	X	X
Secundary outcomes
Appetite	Appetite Questionnaire	X		X		X
Nutritional intake	3-Day food diary	X		X		X
Medication	Medication list	X	X	X	X	X
Body weight	Electronic weighing scale	X	X	X	X	X
Triceps skinfold		X	X	X	X	X
Arm circumference		X	X	X	X	X
Muscle strength	Biceps and quadriceps strength	X		X		X
Muscle strength	Handgrip strength	X	X	X	X	X
Use of professional care services	Diary and health care registration	X	X	X	X	X

* European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30
** Rotterdam Symptom Checklist, overall question ("overall, how did you feel over the past week")
*** Short Fatigue Questionnaire
**** Groningen Activity Restriction Scale

ISSN: 1471-2458