Table 5 Urinary concentration of 1-hydroxypyrene (1OHP) and extent of primary DNA damage in peripheral blood leukocytes in exposed workers and control subjects with respect to metabolic genotypes (CYP1A1, EPHX, and GSTM1). Data reported as the group mean values (± SEM) of individual: urinary concentration of 1OHP (expressed as μg 1OHP/g creatinine), averaged tail intensity values (% of DNA migrated in the comet tail evaluated in 150 cells) and number of AST.

Exposed

   CYP1A1 (MspI)^b w₁/w₁

2.37 ± 0.29*

5.08 ± 2.45*

11.23 ± 0.92*

w₁/m₁ + m₁/m₁

3.33 ± 0.71*

5.81 ± 0.43

13.13 ± 1.65*

   CYP1A1 (Ile/Val)^c w₂/w₂

2.71 ± 0.31*

5.22 ± 0.22*

11.51 ± 0.84*

w₂/m₂ + m₂/m₂

1.96 ± 0.61*

5.85 ± 0.75

13.91 ± 2.95

   EPHX ^d Low

2.17 ± 0.37*,^§

5.22 ± 0.30

12.63 ± 1.12*

Medium + High

3.19 ± 0.45*

5.00 ± 0.30*

10.72 ± 1.16*

   GSTM1 Active

2.53 ± 0.38*

5.46 ± 0.29*

12.14 ± 1,09*

Null

2.79 ± 0.45*

5.05 ± 0.32

11.22 ± 1,21*

Controls

   CYP1A1 (MspI)^b w₁/w₁

0.14 ± 0.02

4.28 ± 0.25

7.24 ± 1.10

w₁/m₁ + m₁/m₁

0.21 ± 0.05

4.87 ± 0.53

6.54 ± 1.30

   CYP1A1 (Ile/Val)^c w₂/w₂

0.14 ± 0.02

4.38 ± 0.24

6.77 ± 0.91

w₂/m₂ + m₂/m₂

0.20 ± 0.07

4.25 ± 0.30

10.86 ± 5.08

   EPHX ^d Low

0.13 ± 0.02

4.58 ± 0.33

7.34 ± 1.13

Medium + High

0.16 ± 0.02

4.21 ± 0.30

6.96 ± 1.43

   GSTM1 Active

0.15 ± 0.02

4.49 ± 0.32

8.32 ± 1,48

Null

0.15 ± 0.03

4.23 ± 0.31

5.67 ± 1,02