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Table 5 Urinary concentration of 1-hydroxypyrene (1OHP) and extent of primary DNA damage in peripheral blood leukocytes in exposed workers and control subjects with respect to metabolic genotypes (CYP1A1, EPHX, and GSTM1). Data reported as the group mean values (± SEM) of individual: urinary concentration of 1OHP (expressed as μg 1OHP/g creatinine), averaged tail intensity values (% of DNA migrated in the comet tail evaluated in 150 cells) and number of AST.

From: Primary DNA damage and genetic polymorphisms for CYP1A1, EPHX and GSTM1 in workers at a graphite electrode manufacturing plant

  1OHP DNA damage
   Averaged counts AST
Exposed    
   CYP1A1 (MspI)b w1/w1 2.37 ± 0.29* 5.08 ± 2.45* 11.23 ± 0.92*
w1/m1 + m1/m1 3.33 ± 0.71* 5.81 ± 0.43 13.13 ± 1.65*
   CYP1A1 (Ile/Val)c w2/w2 2.71 ± 0.31* 5.22 ± 0.22* 11.51 ± 0.84*
w2/m2 + m2/m2 1.96 ± 0.61* 5.85 ± 0.75 13.91 ± 2.95
   EPHX d Low 2.17 ± 0.37*,§ 5.22 ± 0.30 12.63 ± 1.12*
Medium + High 3.19 ± 0.45* 5.00 ± 0.30* 10.72 ± 1.16*
   GSTM1 Active 2.53 ± 0.38* 5.46 ± 0.29* 12.14 ± 1,09*
Null 2.79 ± 0.45* 5.05 ± 0.32 11.22 ± 1,21*
Controls    
   CYP1A1 (MspI)b w1/w1 0.14 ± 0.02 4.28 ± 0.25 7.24 ± 1.10
w1/m1 + m1/m1 0.21 ± 0.05 4.87 ± 0.53 6.54 ± 1.30
   CYP1A1 (Ile/Val)c w2/w2 0.14 ± 0.02 4.38 ± 0.24 6.77 ± 0.91
w2/m2 + m2/m2 0.20 ± 0.07 4.25 ± 0.30 10.86 ± 5.08
   EPHX d Low 0.13 ± 0.02 4.58 ± 0.33 7.34 ± 1.13
Medium + High 0.16 ± 0.02 4.21 ± 0.30 6.96 ± 1.43
   GSTM1 Active 0.15 ± 0.02 4.49 ± 0.32 8.32 ± 1,48
Null 0.15 ± 0.03 4.23 ± 0.31 5.67 ± 1,02
  1. a, b, c, d See notes in Table 2.
  2. * p < 0.05, exposed vs. controls; § p < 0.05, EPHX Low vs. EPHX Medium + High. Non-parametric Mann-Whitney U-test.