Genotype
|
Exposed workers
|
Controlsa
|
---|
CYP1A1 (MspI)b w1/w1
|
79 (72.5)
|
67 (83.8)
|
w1/m1 + m1/m1
|
30 (27.5)
|
13 (16.3)
|
CYP1A1 (Ile/Val)c w2/w2
|
98 (89.9)
|
73 (91.3)
|
w2/m2 + m2/m2
|
11 (10.1)
|
7 (8.8)
|
EPHX
d Low
|
59 (54.1)
|
35 (43.8)
|
Medium + High
|
50 (45.9)
|
45 (56.3)
|
GSTM1 Active
|
63 (57.8)
|
44 (55.0)
|
Null
|
46 (42.2)
|
36 (45.0)
|
-
a Two control subjects were not genotyped.
-
b w1 = common allele, m1 = variant allele.
-
c w2 = common allele; m2 = variant allele.
-
d mEH-deduced activity. The mEH activity deduction was based on the results of genotyping of polymorphisms in exons 3 and 4: subjects carrier of combination (exons 3 and 4) His113His + His139His, His113His + His139Arg, or Tyr113His + His139His, were considered as having "low" activity of mEH; subjects carrier of combination (exons 3 and 4) Tyr113Tyr + His139His, Tyr113His + His139Arg, or His113His + Arg139Arg, were considered as having "medium" activity of mEH; subjects carrier of combination (exons 3 and 4) Tyr113Tyr + His139Arg, Tyr113Tyr + Arg139Arg, or Tyr113His + Arg139Arg, were considered as having "high" activity of mEH [31].