Genotype | Exposed workers | Controlsa
|
---|
CYP1A1 (MspI)b w1/w1
| 79 (72.5) | 67 (83.8) |
w1/m1 + m1/m1
| 30 (27.5) | 13 (16.3) |
CYP1A1 (Ile/Val)c w2/w2
| 98 (89.9) | 73 (91.3) |
w2/m2 + m2/m2
| 11 (10.1) | 7 (8.8) |
EPHX
d Low | 59 (54.1) | 35 (43.8) |
   Medium + High | 50 (45.9) | 45 (56.3) |
GSTM1 Active | 63 (57.8) | 44 (55.0) |
   Null | 46 (42.2) | 36 (45.0) |
-
a Two control subjects were not genotyped.
-
b w1 = common allele, m1 = variant allele.
-
c w2 = common allele; m2 = variant allele.
-
d mEH-deduced activity. The mEH activity deduction was based on the results of genotyping of polymorphisms in exons 3 and 4: subjects carrier of combination (exons 3 and 4) His113His + His139His, His113His + His139Arg, or Tyr113His + His139His, were considered as having "low" activity of mEH; subjects carrier of combination (exons 3 and 4) Tyr113Tyr + His139His, Tyr113His + His139Arg, or His113His + Arg139Arg, were considered as having "medium" activity of mEH; subjects carrier of combination (exons 3 and 4) Tyr113Tyr + His139Arg, Tyr113Tyr + Arg139Arg, or Tyr113His + Arg139Arg, were considered as having "high" activity of mEH [31].