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Table 3 Power to detect given effect sizes (HRs) for associations between exposures with a prevalence of 10% and 20%, for the outcomes of dementia and stroke.

From: The protocols for the 10/66 dementia research group population-based research programme

Minimum Hazard Ratio to be detected

Power for detecting association with 10% exposure prevalence

Power for detecting an association with 20% exposure prevalence

Outcome1,2

Dementia

Stroke

Dementia

Stroke

2.5

100%

99.8%

100%

100%

2.0

96.4%

90.9%

99.8%

98.8%

1.8

86.0%

75.8%

97.5%

92.8%

1.5

48.8%

39.3%

71.0%

59.5%

  1. 1. The power to detect associations with all-cause mortality approximates to 100% in each of these cells
  2. 2. As approximately 70% of dementia cases are categorised as AD, the power of detecting given associations with this outcome is very similar to that for stroke.