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Table 2 Additional contribution of: positive results in EEG and CSF examination (14.3.3 protein test) to diagnosis of probable sporadic CJD; and identified PrP gene mutation to diagnosis of genetic HTSE.

From: Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993–2002

Year of death

Cases solely with positive EEG

Number and percentage of probable sporadic CJD cases

Cases solely with positive CSF 14.3.3 test

Number and percentage of probable sporadic CJD cases

Cases with mutation and negative or missing data on family history.

Number and percentage of genetic TSE cases

1993

52 (95)

-

13 (48)

1994

60 (70)

7 (8)

16 (50)

1995

61 (68)

4 (4)

15 (45)

1996

62 (64)

13 (14)

23 (55)

1997

30 (30)

21 (21)

20 (53)

1998

32 (18)

65 (36)

26 (55)

1999

15 (9)

67 (38)

24 (49)

2000

11 (6)

79 (41)

23 (40)

2001

8 (5)

95 (58)

30 (44)

2002

4 (3)

69 (54)

40 (65)