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Table 1 Study size to obtain 80% statistical power in the proposed screening interventions for different baseline rates for invasive cervical cancer incidence assuming various marginal effects, when α = 0.05 and intervention to control ratio 1:1

From: Alternative technologies in cervical cancer screening: a randomised evaluation trial

Invasive cervical cancer incidence per 105 woman-years1

RR

Woman-years in follow-up (intervention group); 1-sided test

Woman-years in follow-up (intervention group); 2-sided test

5

0.5

820,000

1,020,000

5

0.7

2,467,000

3,097,000

10

0.5

410,000

510,000

10

0.7

1,233,000

1,548,000

15

0.5

273,000

340,000

15

0.7

822,000

1,032,000

20

0.5

205,000

255,000

20

0.7

617,000

774,000

  1. Calculation assumes inclusion of all the ages within organised screening for cervical cancer.
  2. 1 In Finland the baseline rate for invasive cervical cancer incidence is approximately 5, in the combined European material from 10 to 20