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Table 2 Model parameters and values used during sensitivity analysis

From: Estimating the cost-effectiveness of detecting cases of chronic hepatitis C infection on reception into prison

Parameter Baseline value Sensitivity Source (where available)
λ0 = force of infection for new initiates 0.1608 0.1314–0.1942 [13]
λ1 = force of infection for experienced IDUs 0.0526 0.0310–0.0863 [13]
Cost of Doctor £3.49/min (£209.40/hr)   GP:/home visit/min With Qualification costs With direct care staff costs[23]
Cost of Nurse £54/hour   District Nurse (midpoint grade G)/hr with patient + extra costs[23]
Time Taken for BBV lecture/prisoner 10 patients/hr 1 patient/hr – 20 patients/hr [9]
% Nurse time 50% 0–100%  
% Doctor time 50% 0–100%  
Time taken to verbal test on reception into prison 5 min 1–15 min [24]
% Nurse time 50% 0–100% [24]
% Doctor time 50% 0–100% [24]
% Known HCV positive and say so 55% (midpoint) 23%–83% 23%[10], 83%[16],
% never received a positive HCV test but say they are HCV positive 1% 0%–10%  
% IDUs that report IDU use (current or ever) 75% 30–90% Darke[17] reports that IDUs give reasonably reliable answers to questions about drug use.
% non-IDUs that report IDU use (current or ever) 0% 0–20%  
Time Taken to Counsel prior to an ELISA test 25 min 10–60 min 25 min[3] 10–60 min[24]
% Nurse time 50% 0–100% [24]
% Doctor time 50% 0–100% [24]
Time taken to Administer ELISA test 5 min 1–10 min  
% Nurse time 50% 0–100%  
% Doctor time 50% 0–100%  
Cost of ELISA test £12 £5–20 Virus reference department, HPA, Colindale (2005)
% of those offered who accept ELISA testing 85% 10–100% [24]
ELISA Sensitivity 97% 90–100% [24]
ELISA Specificity 99% 90–100% [24]
Time taken to administer PCR test 5 min 1–10 min  
% Nurse Time 50% 0–100%  
% Doctor Time 50% 0–100%  
% of those offered who accept PCR testing 100% 50% Assuming that those that accept an ELISA test will then accept a PCR
PCR Sensitivity 100% 99%–100% [24]
PCR specificity 100% 99–100% [24]
Cost of PCR test £57 £50–80 Virus reference department, HPA, Colindale (2005)
Time taken to counsel the result of negative ELISA or PCR test 5 min 5–15 min  
% Nurse time 50% 0–100%  
% Doctor time 50% 0–100%  
Time taken to counsel the result of a positive ELISA test 25 min 15–75 min [24] 15–75 min[24]
% Nurse time 50% 0–100%  
% Doctor time 50% 0–100%  
Time taken to counsel the result of a positive PCR test 25 min 15–75 min [24] 15–75 min[24]
% Nurse time 50% 0–100%  
% Doctor time 50% 0–100%  
Proportion infected with HCV that become HCV RNA positive 80% 54%–86% [2,25,26]
Rate of HCV testing and diagnosis in the community 0.15 0.1–0.3 See text
Discount rate for costs 3.5% 0%–6% HM Treasury[18]
Discount rate for benefits 3.5% 0%–6% HM Treasury[18]