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Table 5 Summary of major cost, effectiveness and cost-effectiveness results for the strategies assessed if the predicted HIV prevalence is halved, 2004–2023*

From: Cost, affordability and cost-effectiveness of strategies to control tuberculosis in countries with high HIV prevalence

Total annual costs (US$ millions)

Intervention

TB Treatment

AIDS Treatment, excluding ART

ART or TLTI

Total Annual Costs

Total Incremental Cost vs. Baseline Scenario

Baseline scenario†

17.6

32.3

0.0

49.8

N/A

Improve TB Detection Rate

24.3

34.2

0.0

58.4

8.6

Improve TB Cure Rate

23.8

32.9

0.0

56.7

6.8

Improve TB Cure Rate and Case Detection Rate

23.5

34.6

0.0

58.1

8.3

TLTI, 6 months

17.5

32.3

0.401

50.2

0.3

TLTI, Lifetime

17.3

32.3

4.43

54.0

4.2

ART, 50% dropout rate

17.3

31.4

80.3

129.0

79.2

ART, 20% dropout rate

16.7

29.6

180

226.8

176.9

ART, 5% dropout rate

15.7

26.2

337

378.7

328.9

ART to TB patients

17.5

31.5

45.84

94.8

45.0

Total annual effects‡

Intervention

DALYs Gained vs. Baseline Scenario

Deaths Averted vs. Baseline Scenario

TB Cases Averted vs. Baseline Scenario

Baseline scenario†

N/A

N/A

N/A

Improve TB Detection Rate

662,609

28,344

66,677

Improve TB Cure Rate

268,347

11,258

45,780

Improve TB Cure Rate and Case Detection Rate

816,465

34,826

106,872

TLTI, 6 months

6,036

367

1,473

TLTI, Lifetime

16,193

1,120

3,801

ART, 50% dropout rate

311,693

4,566

3,496

ART, 20% dropout rate

453,396

14,214

10,485

ART, 5% dropout rate

662,802

32,773

23,189

ART to TB patients

100,602

3,513

1,360

Cost-effectiveness (US$)§

Intervention

Cost per DALY Gained

Cost per Death Averted

Cost per TB Case Averted

Baseline scenario†

N/A

N/A

N/A

Improve TB Detection Rate

13

303

129

Improve TB Cure Rate

25

606

149

Improve TB Cure Rate and Case Detection Rate

10

237

77

TLTI, 6 months

52

862

215

TLTI, Lifetime

257

3,710

1,090

ART, 50% dropout rate

254

17,300

22,700

ART, 20% dropout rate

390

12,400

16,900

ART, 5% dropout rate

496

10,000

14,200

ART to TB patients

447

12,800

33,100

  1. *Total incremental costs and total incremental effects are average figures across the 20 year period that was considered. Trends over time are shown in the figures.
  2. † The baseline situation is defined as TB treatment only, with a case detection rate of 50% and a cure rate of 70%, and no TLTI or ART.
  3. ‡ In the baseline scenario there are an estimated 648,000 deaths per year and an estimated 224,000 TB cases per year
  4. §Calculated as incremental costs divided by total incremental effects. Numbers are sometimes different to the total costs divided by total effects shown in the table due to rounding.
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BMC Public Health

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