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Table 5 Summary of major cost, effectiveness and cost-effectiveness results for the strategies assessed if the predicted HIV prevalence is halved, 2004–2023*

From: Cost, affordability and cost-effectiveness of strategies to control tuberculosis in countries with high HIV prevalence

Total annual costs (US$ millions)
Intervention TB Treatment AIDS Treatment, excluding ART ART or TLTI Total Annual Costs Total Incremental Cost vs. Baseline Scenario
Baseline scenario† 17.6 32.3 0.0 49.8 N/A
Improve TB Detection Rate 24.3 34.2 0.0 58.4 8.6
Improve TB Cure Rate 23.8 32.9 0.0 56.7 6.8
Improve TB Cure Rate and Case Detection Rate 23.5 34.6 0.0 58.1 8.3
TLTI, 6 months 17.5 32.3 0.401 50.2 0.3
TLTI, Lifetime 17.3 32.3 4.43 54.0 4.2
ART, 50% dropout rate 17.3 31.4 80.3 129.0 79.2
ART, 20% dropout rate 16.7 29.6 180 226.8 176.9
ART, 5% dropout rate 15.7 26.2 337 378.7 328.9
ART to TB patients 17.5 31.5 45.84 94.8 45.0
Total annual effects‡
Intervention DALYs Gained vs. Baseline Scenario Deaths Averted vs. Baseline Scenario TB Cases Averted vs. Baseline Scenario
Baseline scenario† N/A N/A N/A
Improve TB Detection Rate 662,609 28,344 66,677
Improve TB Cure Rate 268,347 11,258 45,780
Improve TB Cure Rate and Case Detection Rate 816,465 34,826 106,872
TLTI, 6 months 6,036 367 1,473
TLTI, Lifetime 16,193 1,120 3,801
ART, 50% dropout rate 311,693 4,566 3,496
ART, 20% dropout rate 453,396 14,214 10,485
ART, 5% dropout rate 662,802 32,773 23,189
ART to TB patients 100,602 3,513 1,360
Cost-effectiveness (US$)§
Intervention Cost per DALY Gained Cost per Death Averted Cost per TB Case Averted
Baseline scenario† N/A N/A N/A
Improve TB Detection Rate 13 303 129
Improve TB Cure Rate 25 606 149
Improve TB Cure Rate and Case Detection Rate 10 237 77
TLTI, 6 months 52 862 215
TLTI, Lifetime 257 3,710 1,090
ART, 50% dropout rate 254 17,300 22,700
ART, 20% dropout rate 390 12,400 16,900
ART, 5% dropout rate 496 10,000 14,200
ART to TB patients 447 12,800 33,100
  1. *Total incremental costs and total incremental effects are average figures across the 20 year period that was considered. Trends over time are shown in the figures.
  2. † The baseline situation is defined as TB treatment only, with a case detection rate of 50% and a cure rate of 70%, and no TLTI or ART.
  3. ‡ In the baseline scenario there are an estimated 648,000 deaths per year and an estimated 224,000 TB cases per year
  4. §Calculated as incremental costs divided by total incremental effects. Numbers are sometimes different to the total costs divided by total effects shown in the table due to rounding.