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Table 4 Summary of major cost, effectiveness and cost-effectiveness results for the strategies assessed, 2004–2013*

From: Cost, affordability and cost-effectiveness of strategies to control tuberculosis in countries with high HIV prevalence

Total annual costs (US$ millions)

Intervention

TB Treatment

AIDS Treatment, excluding ART

ART or TLTI

Total Annual Costs

Total Incremental Cost vs. Baseline Scenario

Baseline scenario†

16.3

61.8

0.0

78.2

N/A

Improve TB Detection Rate

26.3

63.1

0.0

89.4

11.2

Improve TB Cure Rate

23.4

62.1

0.0

85.5

7.3

Improve TB Cure Rate and Case Detection Rate

28.3

63.3

0.0

91.7

13.5

TLTI, 6 months

16.2

61.8

0.646

78.7

0.6

TLTI, Lifetime

16.1

61.8

4.13

82.1

3.9

ART, 50% dropout rate

15.9

59.0

143

217

139

ART, 20% dropout rate

15.2

54.5

277

346

268

ART, 5% dropout rate

14.4

49.6

409

473

395

ART to TB patients

16.2

60.6

47.45

124

46.1

Total annual effects‡

Intervention

DALYs Gained vs. Baseline Scenario

Deaths Averted vs. Baseline Scenario

TB Cases Averted vs. Baseline Scenario

Baseline scenario†

N/A

N/A

N/A

Improve TB Detection Rate

307,158

19,034

34,193

Improve TB Cure Rate

85,223

5,005

24,447

Improve TB Cure Rate and Case Detection Rate

362,939

22,356

58,268

TLTI, 6 months

2,924

346

1,244

TLTI, Lifetime

5,952

836

2,535

ART, 50% dropout rate

444,020

14,313

5,698

ART, 20% dropout rate

578,943

36,105

13,930

ART, 5% dropout rate

706,577

59,075

22,405

ART to TB patients

86,835

5,714

1,045

Cost-effectiveness (US$)§

Intervention

Cost per DALY Gained

Cost per Death Averted

Cost per TB Case Averted

Baseline scenario†

N/A

N/A

N/A

Improve TB Detection Rate

37

591

329

Improve TB Cure Rate

86

1,470

300

Improve TB Cure Rate and Case Detection Rate

37

604

232

TLTI, 6 months

190

1,610

447

TLTI, Lifetime

655

4,660

1,540

ART, 50% dropout rate

314

9,730

24,400

ART, 20% dropout rate

463

7,420

19,200

ART, 5% dropout rate

559

6,690

17,600

ART to TB patients

531

8,070

44,100

  1. *Total incremental costs and total incremental effects are average figures across the 10 year period that was considered. Trends over time are shown in the figures.
  2. † The baseline situation is defined as TB treatment only, with a case detection rate of 50% and a cure rate of 70%, and no TLTI or ART.
  3. ‡ In the baseline scenario there are an estimated 725,000 deaths per year and an estimated 198,000 TB cases per year
  4. §Calculated as incremental costs divided by total incremental effects. Numbers are sometimes different to the total costs divided by total effects shown in the table due to rounding.
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