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Table 4 Summary of major cost, effectiveness and cost-effectiveness results for the strategies assessed, 2004–2013*

From: Cost, affordability and cost-effectiveness of strategies to control tuberculosis in countries with high HIV prevalence

Total annual costs (US$ millions)
Intervention TB Treatment AIDS Treatment, excluding ART ART or TLTI Total Annual Costs Total Incremental Cost vs. Baseline Scenario
Baseline scenario† 16.3 61.8 0.0 78.2 N/A
Improve TB Detection Rate 26.3 63.1 0.0 89.4 11.2
Improve TB Cure Rate 23.4 62.1 0.0 85.5 7.3
Improve TB Cure Rate and Case Detection Rate 28.3 63.3 0.0 91.7 13.5
TLTI, 6 months 16.2 61.8 0.646 78.7 0.6
TLTI, Lifetime 16.1 61.8 4.13 82.1 3.9
ART, 50% dropout rate 15.9 59.0 143 217 139
ART, 20% dropout rate 15.2 54.5 277 346 268
ART, 5% dropout rate 14.4 49.6 409 473 395
ART to TB patients 16.2 60.6 47.45 124 46.1
Total annual effects‡
Intervention DALYs Gained vs. Baseline Scenario Deaths Averted vs. Baseline Scenario TB Cases Averted vs. Baseline Scenario
Baseline scenario† N/A N/A N/A
Improve TB Detection Rate 307,158 19,034 34,193
Improve TB Cure Rate 85,223 5,005 24,447
Improve TB Cure Rate and Case Detection Rate 362,939 22,356 58,268
TLTI, 6 months 2,924 346 1,244
TLTI, Lifetime 5,952 836 2,535
ART, 50% dropout rate 444,020 14,313 5,698
ART, 20% dropout rate 578,943 36,105 13,930
ART, 5% dropout rate 706,577 59,075 22,405
ART to TB patients 86,835 5,714 1,045
Cost-effectiveness (US$)§
Intervention Cost per DALY Gained Cost per Death Averted Cost per TB Case Averted
Baseline scenario† N/A N/A N/A
Improve TB Detection Rate 37 591 329
Improve TB Cure Rate 86 1,470 300
Improve TB Cure Rate and Case Detection Rate 37 604 232
TLTI, 6 months 190 1,610 447
TLTI, Lifetime 655 4,660 1,540
ART, 50% dropout rate 314 9,730 24,400
ART, 20% dropout rate 463 7,420 19,200
ART, 5% dropout rate 559 6,690 17,600
ART to TB patients 531 8,070 44,100
  1. *Total incremental costs and total incremental effects are average figures across the 10 year period that was considered. Trends over time are shown in the figures.
  2. † The baseline situation is defined as TB treatment only, with a case detection rate of 50% and a cure rate of 70%, and no TLTI or ART.
  3. ‡ In the baseline scenario there are an estimated 725,000 deaths per year and an estimated 198,000 TB cases per year
  4. §Calculated as incremental costs divided by total incremental effects. Numbers are sometimes different to the total costs divided by total effects shown in the table due to rounding.