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Table 3 Summary of major cost, effectiveness and cost-effectiveness results for the strategies assessed, 2004–2023*

From: Cost, affordability and cost-effectiveness of strategies to control tuberculosis in countries with high HIV prevalence

Total annual costs (US$ millions)

Intervention

TB Treatment

AIDS Treatment, excluding ART

ART or TLTI

Total Annual Costs

Total Incremental Cost vs. Baseline Scenario

Baseline scenario†

18.5

63.7

0.0

82.2

N/A

Improve TB Detection Rate

27.4

66.7

0.0

94.1

11.9

Improve TB Cure Rate

25.1

64.7

0.0

89.8

7.6

Improve TB Cure Rate and Case Detection Rate

26.9

67.3

0.0

94.2

12.0

TLTI, 6 months

18.3

63.7

0.7

82.8

0.6

TLTI, Lifetime

18.0

63.6

8.0

89.7

7.5

ART, 50% dropout rate

18.2

62.1

153

233

151

ART, 20% dropout rate

17.5

58.8

348

424

342

ART, 5% dropout rate

16.2

52.1

656

725

642

ART to TB patients

18.4

62.5

71.7

152.6

70.5

Total annual effects‡

Intervention

DALYs Gained vs. Baseline Scenario

Deaths Averted vs. Baseline Scenario

TB Cases Averted vs. Baseline Scenario

Baseline scenario†

N/A

N/A

N/A

Improve TB Detection Rate

551,184

26,015

59,436

Improve TB Cure Rate

220,939

10,087

43,378

Improve TB Cure Rate and Case Detection Rate

676,748

31,769

97,795

TLTI, 6 months

7,366

549

2,119

TLTI, Lifetime

20,178

2,075

5,480

ART, 50% dropout rate

585,232

7,390

4,025

ART, 20% dropout rate

834,071

23,794

12,183

ART, 5% dropout rate

1,205,912

56,872

27,446

ART to TB patients

152,604

5,089

1,126

Cost-effectiveness (US$)§

Intervention

Cost per DALY Gained

Cost per Death Averted

Cost per TB Case Averted

Baseline scenario†

N/A

N/A

N/A

Improve TB Detection Rate

21.6

458

201

Improve TB Cure Rate

34.3

752

175

Improve TB Cure Rate and Case Detection Rate

17.8

379

123

TLTI, 6 months

84.7

1,136

294

TLTI, Lifetime

373

3,630

1,374

ART, 50% dropout rate

258

20,461

37,569

ART, 20% dropout rate

410

14,370

28,064

ART, 5% dropout rate

533

11,294

23,403

ART to TB patients

462

13,846

62,578

  1. *Total incremental costs and total incremental effects are average figures across the 20 year period that was considered. Trends over time are shown in the figures.
  2. † The baseline scenario is defined as TB treatment only, with a case detection rate of 50% and a cure rate of 70%, and no TLTI or ART.
  3. ‡ In the baseline scenario there are an estimated 774,000 deaths per year and an estimated 225,000 TB cases per year
  4. §Calculated as incremental costs divided by total incremental effects. Numbers are sometimes different to the total costs divided by total effects shown in the table due to rounding.