Complication and studies | Number vaccinated | S.C. No. | Deaths No. | Risk of complication per million (95% C.I.)a | Risk of death per million (95% C.I.)a | Case fatality risk per hundred (95% C.I.)a | |||
---|---|---|---|---|---|---|---|---|---|
Post-vaccinial encephalitis | |||||||||
Neff 1967a | 7,775,000 | 0 | 0 | 0.0 | (0.0, 0.5) | 0.0 | (0.0, 0.5) | n/a | n/a |
Neff 1967b | 370,000 | 0 | 0 | 0.0 | (0.0, 10.0) | 0.0 | (0.0, 10.0) | n/a | n/a |
Lane 1969 | 8,574,000 | 0 | 0 | 0.0 | (0.0, 0.4) | 0.0 | (0.0, 0.4) | n/a | n/a |
Lane 1970 | 998,000 | 2 | 0 | 2.0 | (0.2, 7.3) | 0.0 | (0.0, 3.7) | 0.0 | (0.0, 84.2) |
Mellin 1970 | 166,000 | 0 | 0 | 0.0 | (0.0, 22.2) | 0.0 | (0.0, 22.2) | n/a | n/a |
Ratner 1970 | 465,926 | 0 | 0 | 0.0 | (0.0, 7.9) | 0.0 | (0.0, 7.9) | n/a | n/a |
Neff 1972 | 433 | 0 | 0 | 0.0 | (0.0, 8483) | 0.0 | (0.0, 8483) | n/a | n/a |
Summary | 18,349,359 | 2 | 0 | 0.1 | (0.01, 0.4) | 0.0 | (0.0, 0.2) | 0.0 | (0, 84.2) |
Vaccinia necrosum | |||||||||
Neff 1967a | 7,775,000 | 2 | 0 | 0.3 | (0.03, 0.9) | 0.0 | (0.0, 0.5) | 0.0 | (0.0, 84.2) |
Neff 1967b | 370,000 | 0 | 0 | 0.0 | (0.0, 10.0) | 0.0 | (0.0, 10.0) | n/a | n/a |
Lane 1969 | 8,574,000 | 6 | 2 | 0.7 | (0.3, 1.5) | 0.2 | (0.03, 0.8) | 33.3 | (4.3, 77.7) |
Lane 1970 | 998,000 | 3 | 0 | 3.0 | (0.6, 8.8) | 0.0 | (0.0, 3.7) | 0.0 | (0.0, 70.8) |
Mellin 1970 | 166,000 | 1 | 0 | 6.0 | (0.2, 33.6) | 0.0 | (0.0, 22.2) | 0.0 | (0.0, 97.5) |
Ratner 1970 | 465,926 | 0 | 0 | 0.0 | (0.0, 7.9) | 0.0 | (0.0, 7.9) | n/a | n/a |
Neff 1972 | 433 | 0 | 0 | 0.0 | (0.0, 8483) | 0.0 | (0.0, 8483) | n/a | n/a |
Summary | 18,349,359 | 12 | 2 | 0.7 | (0.3, 1.1) | 0.1 | (0.01, 0.4) | 16.7 | (2.1, 48.4) |
Eczema vaccinatum | |||||||||
Neff 1967a | 7,775,000 | 3 | 0 | 0.4 | (0.1, 1.1) | 0.0 | (0.0, 0.5) | 0.0 | (0.0, 70.8) |
Neff 1967b | 370,000 | 5 | 0 | 13.5 | (4.4, 31.5) | 0.0 | (0.0, 10.0) | 0.0 | (0.0, 52.2) |
Lane 1969 | 8,574,000 | 8 | 0 | 0.9 | (0.4, 1.8) | 0.0 | (0.0, 0.4) | 0.0 | (0.0, 36.9) |
Lane 1970 | 998,000 | 3 | 0 | 3.0 | (0.6, 8.8) | 0.0 | (0.0, 3.7) | 0.0 | (0.0, 70.8) |
Mellin 1970 | 166,000 | 0 | 0 | 0.0 | (0.0, 22.2) | n/a | n/a | n/a | n/a |
Ratner 1970 | 465,926 | 0 | 0 | 0.0 | (0.0, 7.9) | n/a | n/a | n/a | n/a |
Neff 1972 | 433 | 0 | 0 | 0.0 | (0.0, 8483) | n/a | n/a | n/a | n/a |
Summary | 18,349,359 | 19 | 0 | 1.0 | (0.6, 1.6) | 0.0 | (0.0, 0.2) | 0.0 | (0.0, 17.6) |
Generalized vaccinia | |||||||||
Neff 1967a | 7,775,000 | 3 | 0 | 0.4 | (0.1, 1.1) | n/c | n/c | n/c | n/c |
Neff 1967b | 370,000 | 1 | 0 | 2.7 | (0.1, 15.1) | n/c | n/c | n/c | n/c |
Lane 1969 | 8,574,000 | 10 | 0 | 1.2 | (0.6, 2.1) | n/c | n/c | n/c | n/c |
Lane 1970 | 998,000 | 9 | 0 | 9.0 | (4.1, 17.1) | n/c | n/c | n/c | n/c |
Mellin 1970 | 166,000 | 1 | 0 | 6.0 | (0.2, 33.6) | n/c | n/c | n/c | n/c |
Ratner 1970 | 465,926 | 1 | 0 | 2.1 | (0.05, 12.0) | n/c | n/c | n/c | n/c |
Neff 1972 | 433 | 0 | 0 | 0.0 | (0.0, 8483) | n/a | n/a | n/a | n/a |
Summary | 18,349,359 | 25 | 0 | 1.4 | (0.9, 2.0) | n/c | n/c | n/c | n/c |
Accidental inoculation | |||||||||
Neff 1967a | 7,775,000 | 8 | 0 | 1.0 | (0.4, 2.0) | n/c | n/c | n/c | n/c |
Neff 1967b | 370,000 | 250 | 0 | 675.7 | (594, 765) | n/c | n/c | n/c | n/c |
Lane 1969 | 8,574,000 | 7 | 0 | 0.8 | (0.3, 1.7) | n/c | n/c | n/c | n/c |
Lane 1970 | 998,000 | 42 | 0 | 42.1 | (30.3, 56.9) | n/c | n/c | n/c | n/c |
Mellin 1970 | 166,000 | 3 | 0 | 18.1 | (3.7, 52.8) | n/c | n/c | n/c | n/c |
Ratner 1970 | 465,926 | 1 | 0 | 2.1 | (0.05, 12.0) | n/c | n/c | n/c | n/c |
Neff 1972 | 433 | 0 | 0 | 0.0 | (0.0, 8483) | n/a | n/a | n/a | n/a |
Summary | 18,349,359 | 311 | 0 | 16.9 | (15.1, 18.9) | n/c | n/c | n/c | n/c |