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Table 6 Risk of serious complications (S.C.) and death from smallpox re-vaccinations for ages greater than 1, 1963–1968

From: Risks of serious complications and death from smallpox vaccination: A systematic review of the United States experience, 1963–1968

Complication and studies Number vaccinated S.C. No. Deaths No. Risk of complication per million (95% C.I.)a Risk of death per million (95% C.I.)a Case fatality risk per hundred (95% C.I.)a
Post-vaccinial encephalitis          
   Neff 1967a 7,775,000 0 0 0.0 (0.0, 0.5) 0.0 (0.0, 0.5) n/a n/a
   Neff 1967b 370,000 0 0 0.0 (0.0, 10.0) 0.0 (0.0, 10.0) n/a n/a
   Lane 1969 8,574,000 0 0 0.0 (0.0, 0.4) 0.0 (0.0, 0.4) n/a n/a
   Lane 1970 998,000 2 0 2.0 (0.2, 7.3) 0.0 (0.0, 3.7) 0.0 (0.0, 84.2)
   Mellin 1970 166,000 0 0 0.0 (0.0, 22.2) 0.0 (0.0, 22.2) n/a n/a
   Ratner 1970 465,926 0 0 0.0 (0.0, 7.9) 0.0 (0.0, 7.9) n/a n/a
   Neff 1972 433 0 0 0.0 (0.0, 8483) 0.0 (0.0, 8483) n/a n/a
   Summary 18,349,359 2 0 0.1 (0.01, 0.4) 0.0 (0.0, 0.2) 0.0 (0, 84.2)
Vaccinia necrosum          
   Neff 1967a 7,775,000 2 0 0.3 (0.03, 0.9) 0.0 (0.0, 0.5) 0.0 (0.0, 84.2)
   Neff 1967b 370,000 0 0 0.0 (0.0, 10.0) 0.0 (0.0, 10.0) n/a n/a
   Lane 1969 8,574,000 6 2 0.7 (0.3, 1.5) 0.2 (0.03, 0.8) 33.3 (4.3, 77.7)
   Lane 1970 998,000 3 0 3.0 (0.6, 8.8) 0.0 (0.0, 3.7) 0.0 (0.0, 70.8)
   Mellin 1970 166,000 1 0 6.0 (0.2, 33.6) 0.0 (0.0, 22.2) 0.0 (0.0, 97.5)
   Ratner 1970 465,926 0 0 0.0 (0.0, 7.9) 0.0 (0.0, 7.9) n/a n/a
   Neff 1972 433 0 0 0.0 (0.0, 8483) 0.0 (0.0, 8483) n/a n/a
   Summary 18,349,359 12 2 0.7 (0.3, 1.1) 0.1 (0.01, 0.4) 16.7 (2.1, 48.4)
Eczema vaccinatum          
   Neff 1967a 7,775,000 3 0 0.4 (0.1, 1.1) 0.0 (0.0, 0.5) 0.0 (0.0, 70.8)
   Neff 1967b 370,000 5 0 13.5 (4.4, 31.5) 0.0 (0.0, 10.0) 0.0 (0.0, 52.2)
   Lane 1969 8,574,000 8 0 0.9 (0.4, 1.8) 0.0 (0.0, 0.4) 0.0 (0.0, 36.9)
   Lane 1970 998,000 3 0 3.0 (0.6, 8.8) 0.0 (0.0, 3.7) 0.0 (0.0, 70.8)
   Mellin 1970 166,000 0 0 0.0 (0.0, 22.2) n/a n/a n/a n/a
   Ratner 1970 465,926 0 0 0.0 (0.0, 7.9) n/a n/a n/a n/a
   Neff 1972 433 0 0 0.0 (0.0, 8483) n/a n/a n/a n/a
   Summary 18,349,359 19 0 1.0 (0.6, 1.6) 0.0 (0.0, 0.2) 0.0 (0.0, 17.6)
Generalized vaccinia          
   Neff 1967a 7,775,000 3 0 0.4 (0.1, 1.1) n/c n/c n/c n/c
   Neff 1967b 370,000 1 0 2.7 (0.1, 15.1) n/c n/c n/c n/c
   Lane 1969 8,574,000 10 0 1.2 (0.6, 2.1) n/c n/c n/c n/c
   Lane 1970 998,000 9 0 9.0 (4.1, 17.1) n/c n/c n/c n/c
   Mellin 1970 166,000 1 0 6.0 (0.2, 33.6) n/c n/c n/c n/c
   Ratner 1970 465,926 1 0 2.1 (0.05, 12.0) n/c n/c n/c n/c
   Neff 1972 433 0 0 0.0 (0.0, 8483) n/a n/a n/a n/a
   Summary 18,349,359 25 0 1.4 (0.9, 2.0) n/c n/c n/c n/c
Accidental inoculation          
   Neff 1967a 7,775,000 8 0 1.0 (0.4, 2.0) n/c n/c n/c n/c
   Neff 1967b 370,000 250 0 675.7 (594, 765) n/c n/c n/c n/c
   Lane 1969 8,574,000 7 0 0.8 (0.3, 1.7) n/c n/c n/c n/c
   Lane 1970 998,000 42 0 42.1 (30.3, 56.9) n/c n/c n/c n/c
   Mellin 1970 166,000 3 0 18.1 (3.7, 52.8) n/c n/c n/c n/c
   Ratner 1970 465,926 1 0 2.1 (0.05, 12.0) n/c n/c n/c n/c
   Neff 1972 433 0 0 0.0 (0.0, 8483) n/a n/a n/a n/a
   Summary 18,349,359 311 0 16.9 (15.1, 18.9) n/c n/c n/c n/c
  1. n/a = not assessable, n/c = not calculated aExact confidence intervals based on the binomial distribution
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