Generalized vaccinia | Accidental infection | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Age group and studies | Number vaccinated | G.V. No. | Deaths No. | Risk of complication per million (95% C.I.)a | Number vaccinated | A.I. No. | Deaths No. | Risk of complication per million (95% C.I.)a | ||
Age <1 | ||||||||||
Neff 1967a | 654,000 | 52 | 0 | 79.5 | (59.4, 104) | 654,000 | 7 | 0 | 10.7 | (4.3, 22.0) |
Neff 1967b | 31,000 | 12 | 0 | 387.1 | (200, 676) | n/a | n/a | n/a | n/a | n/a |
Lane 1969 | 614,000 | 43 | 0 | 70.0 | (50.7, 94.3) | 614,000 | 7 | 0 | 11.4 | (4.6, 23.5) |
Lane 1970 | 17,000 | 28 | 0 | 1647 | (1095, 2380) | 17,000 | 36 | 0 | 2117.6 | (1484, 2930) |
Ratner 1970 | 1 | 1 | 0 | n/c | n/c | 1 | 0 | 0 | n/c | n/c |
Neff 1972 | 32 | 0 | 0 | n/c | n/c | 32 | 0 | 0 | n/c | n/c |
Summary | 1,316,033 | 136 | 0 | 103.3 | (86.7, 122.2) | 1,285,033 | 50 | 0 | 38.9 | (28.9, 51.3) |
Age 1 to 4 | ||||||||||
Neff 1967a | 2,973,000 | 46 | 0 | 15.5 | (11.3, 20.6) | 2,973,000 | 40 | 0 | 13.4 | (9.6, 18.3) |
Neff 1967b | 142,000 | 24 | 0 | 169.0 | (108, 251) | n/a | n/a | n/a | n/a | n/a |
Lane 1969 | 2,733,000 | 47 | 0 | 17.2 | (12.6, 22.9) | 2,733,000 | 91 | 0 | 33.3 | (26.8, 40.9) |
Lane 1970 | 317,000 | 74 | 0 | 233.4 | (183, 293) | 317,000 | 183 | 0 | 577.3 | (497, 667) |
Ratner 1970 | 68,002 | 6 | 0 | 88.2 | (32.4, 192) | 68,002 | 3 | 0 | 44.1 | (9.1, 129) |
Neff 1972 | 517 | 0 | 0 | 0.0 | (0.0, 7110) | 517 | 3 | 0 | 5802.7 | (1198, 16,864) |
Summary | 6,233,519 | 197 | 0 | 31.6 | (27.3, 36.3) | 6,091,519 | 320 | 0 | 52.5 | (46.9, 58.6) |
Age 5 to 19 | ||||||||||
Neff 1967a | 2,295,000 | 24 | 0 | 10.5 | (6.7, 15.6) | 2,295,000 | 33 | 0 | 14.4 | (9.9, 20.2) |
Neff 1967b | 110,000 | 17 | 0 | 154.5 | (90.0, 247) | n/a | n/a | n/a | n/a | n/a |
Lane 1969 | 1,959,000 | 25 | 0 | 12.8 | (8.3, 18.8) | 1,959,000 | 35 | 0 | 17.9 | (12.4, 24.8) |
Lane 1970 | 229,000 | 32 | 0 | 139.7 | (95.6, 197) | 229,000 | 85 | 0 | 371.2 | (296, 459) |
Ratner 1970b | 193,721 | 9 | 0 | 46.5 | (21.2, 88.2) | 193,721 | 2 | 0 | 10.3 | (1.2, 37.3) |
Summary | 4,786,721 | 107 | 0 | 22.4 | (18.3, 27.0) | 4,676,721 | 155 | 0 | 33.1 | (28.1, 38.8) |
Age 20 + | ||||||||||
Neff 1967a | 317,000 | 6 | 0 | 18.9 | (6.9, 41.2) | 317,000 | 4 | 0 | 12.6 | (3.4, 32.3) |
Neff 1967b | 15,000 | 2 | 0 | 133.3 | (16.1, 482) | n/a | n/a | n/a | n/a | n/a |
Lane 1969 | 288,000 | 13 | 0 | 45.1 | (24.0, 77.2) | 288,000 | 4 | 0 | 13.9 | (3.8, 35.6) |
Lane 1970 | 33,000 | 7 | 0 | 212.1 | (85.3, 437) | 33,000 | 20 | 0 | 606.1 | (370, 936) |
Ratner 1970b | 107,822 | 10 | 0 | 92.7 | (44.5, 171) | 107,822 | 8 | 0 | 74.2 | (32.0, 146) |
Summary | 760,822 | 38 | 0 | 49.9 | (35.3, 68.6) | 745,822 | 36 | 0 | 48.3 | (33.8, 66.8) |
All agesc | ||||||||||
Neff 1967a | 6,239,000 | 130 | 0 | 20.8 | (17.4, 24.7) | 6,239,000 | 85 | 0 | 13.6 | (10.9, 16.8) |
Neff 1967b | 298,000 | 71 | 0 | 238.3 | (186.1, 300) | 298,000 | 250 | 0 | 838.9 | (738, 950) |
Lane 1969 | 5,594,000 | 131 | 0 | 23.4 | (19.6, 27.8) | 5,594,000 | 142 | 0 | 25.4 | (21.4, 23.0) |
Lane 1970 | 596,000 | 157 | 0 | 263.4 | (224, 308) | 596,000 | 344 | 0 | 577.2 | (518, 641) |
Mellin 1970 | 109,000 | 12 | 0 | 110.1 | (56.9, 192) | 109,000 | 20 | 0 | 183.5 | (112, 283) |
Ratner 1970 | 369,546 | 26 | 0 | 70.4 | (46.0, 103) | 369,546 | 13 | 0 | 35.2 | (18.7, 60.1) |
Neff 1972 | 549 | 0 | 0 | 0.0 | (0.0, 6697) | 549 | 3 | 0 | 5464.5 | (1128, 15,885) |
Summary | 13,206,095 | 527 | 0 | 39.9 | (36.6, 43.5) | 13,206,095 | 857 | 0 | 64.9 | (60.6, 69.4) |