| | |
Generalized vaccinia
|
Accidental infection
|
|---|
|
Age group and studies
|
Number vaccinated
|
G.V. No.
|
Deaths No.
|
Risk of complication per million (95% C.I.)a
|
Number vaccinated
|
A.I. No.
|
Deaths No.
|
Risk of complication per million (95% C.I.)a
|
|---|
|
Age <1
| | | | | | | | | | |
|
Neff 1967a
|
654,000
|
52
|
0
|
79.5
|
(59.4, 104)
|
654,000
|
7
|
0
|
10.7
|
(4.3, 22.0)
|
|
Neff 1967b
|
31,000
|
12
|
0
|
387.1
|
(200, 676)
|
n/a
|
n/a
|
n/a
|
n/a
|
n/a
|
|
Lane 1969
|
614,000
|
43
|
0
|
70.0
|
(50.7, 94.3)
|
614,000
|
7
|
0
|
11.4
|
(4.6, 23.5)
|
|
Lane 1970
|
17,000
|
28
|
0
|
1647
|
(1095, 2380)
|
17,000
|
36
|
0
|
2117.6
|
(1484, 2930)
|
|
Ratner 1970
|
1
|
1
|
0
|
n/c
|
n/c
|
1
|
0
|
0
|
n/c
|
n/c
|
|
Neff 1972
|
32
|
0
|
0
|
n/c
|
n/c
|
32
|
0
|
0
|
n/c
|
n/c
|
|
Summary
|
1,316,033
|
136
|
0
|
103.3
|
(86.7, 122.2)
|
1,285,033
|
50
|
0
|
38.9
|
(28.9, 51.3)
|
|
Age 1 to 4
| | | | | | | | | | |
|
Neff 1967a
|
2,973,000
|
46
|
0
|
15.5
|
(11.3, 20.6)
|
2,973,000
|
40
|
0
|
13.4
|
(9.6, 18.3)
|
|
Neff 1967b
|
142,000
|
24
|
0
|
169.0
|
(108, 251)
|
n/a
|
n/a
|
n/a
|
n/a
|
n/a
|
|
Lane 1969
|
2,733,000
|
47
|
0
|
17.2
|
(12.6, 22.9)
|
2,733,000
|
91
|
0
|
33.3
|
(26.8, 40.9)
|
|
Lane 1970
|
317,000
|
74
|
0
|
233.4
|
(183, 293)
|
317,000
|
183
|
0
|
577.3
|
(497, 667)
|
|
Ratner 1970
|
68,002
|
6
|
0
|
88.2
|
(32.4, 192)
|
68,002
|
3
|
0
|
44.1
|
(9.1, 129)
|
|
Neff 1972
|
517
|
0
|
0
|
0.0
|
(0.0, 7110)
|
517
|
3
|
0
|
5802.7
|
(1198, 16,864)
|
|
Summary
|
6,233,519
|
197
|
0
|
31.6
|
(27.3, 36.3)
|
6,091,519
|
320
|
0
|
52.5
|
(46.9, 58.6)
|
|
Age 5 to 19
| | | | | | | | | | |
|
Neff 1967a
|
2,295,000
|
24
|
0
|
10.5
|
(6.7, 15.6)
|
2,295,000
|
33
|
0
|
14.4
|
(9.9, 20.2)
|
|
Neff 1967b
|
110,000
|
17
|
0
|
154.5
|
(90.0, 247)
|
n/a
|
n/a
|
n/a
|
n/a
|
n/a
|
|
Lane 1969
|
1,959,000
|
25
|
0
|
12.8
|
(8.3, 18.8)
|
1,959,000
|
35
|
0
|
17.9
|
(12.4, 24.8)
|
|
Lane 1970
|
229,000
|
32
|
0
|
139.7
|
(95.6, 197)
|
229,000
|
85
|
0
|
371.2
|
(296, 459)
|
|
Ratner 1970b
|
193,721
|
9
|
0
|
46.5
|
(21.2, 88.2)
|
193,721
|
2
|
0
|
10.3
|
(1.2, 37.3)
|
|
Summary
|
4,786,721
|
107
|
0
|
22.4
|
(18.3, 27.0)
|
4,676,721
|
155
|
0
|
33.1
|
(28.1, 38.8)
|
|
Age 20 +
| | | | | | | | | | |
|
Neff 1967a
|
317,000
|
6
|
0
|
18.9
|
(6.9, 41.2)
|
317,000
|
4
|
0
|
12.6
|
(3.4, 32.3)
|
|
Neff 1967b
|
15,000
|
2
|
0
|
133.3
|
(16.1, 482)
|
n/a
|
n/a
|
n/a
|
n/a
|
n/a
|
|
Lane 1969
|
288,000
|
13
|
0
|
45.1
|
(24.0, 77.2)
|
288,000
|
4
|
0
|
13.9
|
(3.8, 35.6)
|
|
Lane 1970
|
33,000
|
7
|
0
|
212.1
|
(85.3, 437)
|
33,000
|
20
|
0
|
606.1
|
(370, 936)
|
|
Ratner 1970b
|
107,822
|
10
|
0
|
92.7
|
(44.5, 171)
|
107,822
|
8
|
0
|
74.2
|
(32.0, 146)
|
|
Summary
|
760,822
|
38
|
0
|
49.9
|
(35.3, 68.6)
|
745,822
|
36
|
0
|
48.3
|
(33.8, 66.8)
|
|
All agesc
| | | | | | | | | | |
|
Neff 1967a
|
6,239,000
|
130
|
0
|
20.8
|
(17.4, 24.7)
|
6,239,000
|
85
|
0
|
13.6
|
(10.9, 16.8)
|
|
Neff 1967b
|
298,000
|
71
|
0
|
238.3
|
(186.1, 300)
|
298,000
|
250
|
0
|
838.9
|
(738, 950)
|
|
Lane 1969
|
5,594,000
|
131
|
0
|
23.4
|
(19.6, 27.8)
|
5,594,000
|
142
|
0
|
25.4
|
(21.4, 23.0)
|
|
Lane 1970
|
596,000
|
157
|
0
|
263.4
|
(224, 308)
|
596,000
|
344
|
0
|
577.2
|
(518, 641)
|
|
Mellin 1970
|
109,000
|
12
|
0
|
110.1
|
(56.9, 192)
|
109,000
|
20
|
0
|
183.5
|
(112, 283)
|
|
Ratner 1970
|
369,546
|
26
|
0
|
70.4
|
(46.0, 103)
|
369,546
|
13
|
0
|
35.2
|
(18.7, 60.1)
|
|
Neff 1972
|
549
|
0
|
0
|
0.0
|
(0.0, 6697)
|
549
|
3
|
0
|
5464.5
|
(1128, 15,885)
|
|
Summary
|
13,206,095
|
527
|
0
|
39.9
|
(36.6, 43.5)
|
13,206,095
|
857
|
0
|
64.9
|
(60.6, 69.4)
|
- n/c = not calculated, n/a = not available from this study aRisk and confidence intervals not calculated (n/c) for less that 100 vaccinations. Exact confidence intervals based on the binomial distribution. bThe Ratner study age groups, "Age 5 to 14" and "Age 15+", were counted in the Table age groups "Age 5 to 19" and "Age 20+", respectively. cAll ages group includes subjects whose age was unknown
